2-PHENYLPYRIMIDINE

Base Information

• Chemical Name: 2-PHENYLPYRIMIDINE
• CAS No.: 7431-45-0
• Molecular Formula: C10H8N2
• Molecular Weight: 156.187
• Hs Code.: 2933599590
• Mol file: 7431-45-0.mol

Synonyms:2-Phenylpyrimidine;phenylpyrimidine;

Chemical Property of 2-PHENYLPYRIMIDINE

Chemical Property:

• Vapor Pressure: 0.84mmHg at 25°C
• Melting Point: 37.0 to 41.0 °C
• Refractive Index: 1.58
• Boiling Point: 188.1 °C at 760 mmHg
• PKA: 1.00±0.13(Predicted)
• Flash Point: 51.4 °C
• PSA: 25.78000
• Density: 1.106 g/cm³
• LogP: 2.14360
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-phenylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYLPYRIMIDINE

There total 71 articles about 2-PHENYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-chloropyrimidine (1722-12-9,1195939-87-7) + phenylboronic acid (98-80-6) → 2-phenylpyrimidine (7431-45-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; at 90 ℃;

DOI:10.1002/ejoc.201000631

Reference yield: 97.0%

2-bromopyrimidine (4595-60-2) + phenylboronic acid (98-80-6) → 2-phenylpyrimidine (7431-45-0)

Guidance literature:

With sodium carbonate; In ethanol; water; at 90 ℃; for 7h; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.05.064

Reference yield: 91.0%

2-chloropyrimidine (1722-12-9,1195939-87-7) + triphenylindium (3958-47-2) → 2-phenylpyrimidine (7431-45-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.3390/molecules23071582

upstream raw materials:

2-phenyl-1,4,5,6-tetrahydropyrimidine

5-chloro-2-phenylpyrimidine

4-chloro-2-phenylpyrimidine

(E)-3-(diethylamino)acrylaldehyde

Downstream raw materials:

2-(3-nitrophenyl)pyrimidine

2-(2,6-distyrylphenyl)pyrimidine

2-(2-(methylthio)phenyl)pyrimidine

5-phenyl-2-[2-(pyrimidin-2-yl)phenyl]oxazole

Refernces

• 1、 Bagherzadeh, Nastaran,Sardarian, Ali Reza,Eslahi, Hassan. "Sustainable and recyclable magnetic nanocatalyst of 1,10-phenanthroline Pd(0) complex in green synthesis of biaryls and tetrazoles using arylboronic acids as versatile substrates". . . Retrieved 2021/04/02.
• 2、 Le, Yi,Zhang, Yan,Wang, Qin,Rao, Nian,Li, Dan,Liu, Li,Ouyang, Guiping,Yan, Longjia. "Microwave-assisted synthesis of phenylpyrimidine derivatives via Suzuki-Miyaura reactions in water". supporting information. . Retrieved 2021/02/21.