ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate
• CAS No.: 1447711-35-4
• Molecular Formula: C₂₈H₃₅NO₃
• Molecular Weight: 433.591
• Mol file: 1447711-35-4.mol

Synonyms:ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate

Chemical Property of ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate

There total 9 articles about ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate (1447711-33-2) + ethyl iodide (75-03-6) → ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate (1447711-35-4)

Guidance literature:

ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

ethyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

DOI:10.1021/acs.jmedchem.8b00106

Reference yield: 85.0%

ethyl bromide (74-96-4) + ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate (1447711-33-2) → ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate (1447711-35-4)

Guidance literature:

ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

ethyl bromide; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 5h;

DOI:10.1016/j.ejmech.2018.08.085

Reference yield: 85.0%

ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate (1447711-33-2) → ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate (1447711-35-4)

Guidance literature:

ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

ethyl halogenide; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 5h;

DOI:10.1021/acs.jmedchem.0c01197

upstream raw materials:

4-hydroxy-3-methylbenzoic acid

ethyl 1H-pyrrole-2-carboxylate

ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate

ethyl iodide