2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

Base Information

Chemical Name:2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone
CAS No.:1418297-41-2
Molecular Formula:C₂₁H₁₈F₄N₂O₂
Molecular Weight:406.38
Hs Code.:

Synonyms:2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

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Chemical Property of 2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

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Technology Process of 2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

There total 9 articles about 2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1418297-40-1
2-hydroxy-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

: 1418297-41-2
2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 ℃; for 0.25h;

Reference yield:

: 1085454-04-1
5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carbaldehyde

: 1418297-41-2
2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium ethanolate / ethanol / 4 h

2: 4-methylmorpholine N-oxide; osmium(VIII) oxide / acetone; tert-butyl alcohol / 20 °C

3: water; sodium dithionite / N,N-dimethyl-formamide / 1.5 h / 100 °C

4: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / 0 °C

With osmium(VIII) oxide; sodium dithionite; diethylamino-sulfur trifluoride; water; sodium ethanolate; 4-methylmorpholine N-oxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

Reference yield:

: 1418297-39-8
1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)-phenyl]ethane-1,2-dione

: 1418297-41-2
2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium dithionite / N,N-dimethyl-formamide / 1.5 h / 100 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / 0 °C

With sodium dithionite; diethylamino-sulfur trifluoride; water; In dichloromethane; N,N-dimethyl-formamide;