2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanol

Base Information

Chemical Name:2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanol
CAS No.:1418297-36-5
Molecular Formula:C₂₁H₂₀F₄N₂O₂
Molecular Weight:408.396
Hs Code.:

Synonyms:2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanol

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Chemical Property of 2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanol

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Technology Process of 2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanol

There total 10 articles about 2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1418297-41-2
2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

: 1418297-36-5
2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanol

Guidance literature:: With sodium tetrahydroborate; ethanol; at 0 - 20 ℃; for 0.583333h;

Reference yield:

: 1418297-40-1
2-hydroxy-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

: 1418297-36-5
2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / 0 °C

2: sodium tetrahydroborate; ethanol / 0.58 h / 0 - 20 °C

With sodium tetrahydroborate; ethanol; diethylamino-sulfur trifluoride; In dichloromethane;

Reference yield:

: 1085454-04-1
5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carbaldehyde

: 1418297-36-5
2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: sodium ethanolate / ethanol / 4 h

2: 4-methylmorpholine N-oxide; osmium(VIII) oxide / acetone; tert-butyl alcohol / 20 °C

3: water; sodium dithionite / N,N-dimethyl-formamide / 1.5 h / 100 °C

4: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / 0 °C

5: sodium tetrahydroborate; ethanol / 0.58 h / 0 - 20 °C

With sodium tetrahydroborate; osmium(VIII) oxide; sodium dithionite; ethanol; diethylamino-sulfur trifluoride; water; sodium ethanolate; 4-methylmorpholine N-oxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;