3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

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Chemical Name:3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1-(4-methylbenzyl)-1H-pyrazole
CAS No.:1418296-72-6
Molecular Formula:C₂₁H₁₈F₄N₂O
Molecular Weight:390.38
Hs Code.:

Synonyms:3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

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Chemical Property of 3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

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Technology Process of 3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

There total 11 articles about 3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1-(4-methylbenzyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1418297-36-5
2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanol

: 1418296-72-6
3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

Guidance literature:: 2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanol; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 20h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 20 ℃; for 4h;

Reference yield:

: 1418297-40-1
2-hydroxy-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

: 1418296-72-6
3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / 0 °C

2.1: sodium tetrahydroborate; ethanol / 0.58 h / 0 - 20 °C

3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 20 h / 0 - 20 °C

3.2: 4 h / 20 °C

With sodium tetrahydroborate; ethanol; diethylamino-sulfur trifluoride; methanesulfonyl chloride; triethylamine; In dichloromethane;

Reference yield:

: 1418297-41-2
2-fluoro-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

: 1418296-72-6
3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate; ethanol / 0.58 h / 0 - 20 °C

2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 20 h / 0 - 20 °C

2.2: 4 h / 20 °C

With sodium tetrahydroborate; ethanol; methanesulfonyl chloride; triethylamine; In dichloromethane;