2-(2-methoxycarbonylamino-ethyl)-6-nitro-benzoic acid methylester

Base Information

Chemical Name:2-(2-methoxycarbonylamino-ethyl)-6-nitro-benzoic acid methylester
CAS No.:878160-02-2
Molecular Formula:C₁₂H₁₄N₂O₆
Molecular Weight:282.253
Hs Code.:

Synonyms:2-(2-methoxycarbonylamino-ethyl)-6-nitro-benzoic acid methylester

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Chemical Property of 2-(2-methoxycarbonylamino-ethyl)-6-nitro-benzoic acid methylester

Chemical Property:

Boiling Point:467.3±40.0 °C(Predicted)
Density:1.298±0.06 g/cm3(Predicted)

Purity/Quality:

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Technology Process of 2-(2-methoxycarbonylamino-ethyl)-6-nitro-benzoic acid methylester

There total 8 articles about 2-(2-methoxycarbonylamino-ethyl)-6-nitro-benzoic acid methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: C₁₁H₁₀N₄O₅

: 878160-02-2
2-(2-methoxycarbonylamino-ethyl)-6-nitro-benzoic acid methylester

Guidance literature:: With methanol; copper dichloride; In toluene; at 80 ℃; for 2h;

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 878160-02-2
2-(2-methoxycarbonylamino-ethyl)-6-nitro-benzoic acid methylester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 40 percent / KMnO₄; Na₂CO₃ / H₂O / 18 h / 100 °C

2.1: 100 percent / Cs₂CO₃ / methanol; dimethylformamide / 14 h / 0 - 20 °C

3.1: 100 percent / Pd(Ph₃P)4 / toluene / 20 h / 110 °C

4.1: BH₃*SMe₂ / tetrahydrofuran / 4 h / 0 °C

4.2: 90 percent / H₂O₂; NaOH / 1 h / 20 °C

5.1: 80 percent / CrO₃; H₂SO₄ / 4 h / 0 - 20 °C

6.1: (PhO)2P(O)N₃; Et₃N / toluene / 2 h / 80 °C

7.1: CuCl₂ / 2 h / 80 °C

With chromium(VI) oxide; potassium permanganate; dimethylsulfide borane complex; sulfuric acid; diphenyl phosphoryl azide; sodium carbonate; caesium carbonate; triethylamine; copper dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2007-965978

Reference yield:

: 38876-67-4
2-bromo-6-nitrobenzoic acid

: 878160-02-2
2-(2-methoxycarbonylamino-ethyl)-6-nitro-benzoic acid methylester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / Cs₂CO₃ / methanol; dimethylformamide / 14 h / 0 - 20 °C

2.1: 100 percent / Pd(Ph₃P)4 / toluene / 20 h / 110 °C

3.1: BH₃*SMe₂ / tetrahydrofuran / 4 h / 0 °C

3.2: 90 percent / H₂O₂; NaOH / 1 h / 20 °C

4.1: 80 percent / CrO₃; H₂SO₄ / 4 h / 0 - 20 °C

5.1: (PhO)2P(O)N₃; Et₃N / toluene / 2 h / 80 °C

6.1: CuCl₂ / 2 h / 80 °C

With chromium(VI) oxide; dimethylsulfide borane complex; sulfuric acid; diphenyl phosphoryl azide; caesium carbonate; triethylamine; copper dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2007-965978