349-55-3

Basic information

• Product Name: 3-Methoxy-5-(trifluoromethyl)aniline
• Synonyms: 3-(trifluoromethyl)-5-methoxybenzenamine;3-Methoxy-5-(trifluoromethyl)aniline, 5-Methoxy-alpha,alpha,alpha-trifluoro-m-toluidine, 5-(Trifluoromethyl)-m-anisidine;3-AMino-5-(trifluoroMethyl)anisole[3-Methoxy-5-(trifluoroMethyl)aniline];Benzenamine, 3-methoxy-5-(trifluoromethyl)-;3-Methoxy-5-(trifluoromethyl)anil;3-METHOXY-5-TRIFLUOROMETHYL-PHENYLAMINE;3-METHOXY-5-(TRIFLUOROMETHYL)ANILINE;3-AMINO-5-METHOXYBENZOTRIFLUORIDE
• CAS NO: 349-55-3
• Molecular Formula: C₈H₈F₃NO
• Molecular Weight: 191.15
• EINECS: 206-487-8
• Product Categories: NULL;Amines and Anilines;Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 349-55-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 50-52 °C(lit.)
• Boiling Point: 242 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.28 g/cm³
• Vapor Pressure: 0.0348mmHg at 25°C
• Refractive Index: 1.476
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.95±0.10(Predicted)
• CAS DataBase Reference: 3-Methoxy-5-(trifluoromethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxy-5-(trifluoromethyl)aniline(349-55-3)
• EPA Substance Registry System: 3-Methoxy-5-(trifluoromethyl)aniline(349-55-3)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-23-22
• Safety Statements: 26-37/39-24/25
• RIDADR: PG3
• WGK Germany: 3
• HazardClass: 6.1
• Hazardous Substances Data: 349-55-3(Hazardous Substances Data)

Usage

Uses

3-Methoxy-5-(trifluoromethyl)aniline was used in the synthesis of spleen tyrosine kinase inhibitors based on the phenylamino pyrimidine thiazole.

InChI:InChI=1/C8H8F3NO/c1-13-7-3-5(8(9,10)11)2-6(12)4-7/h2-4H,12H2,1H3

Upstream product

• 401-99-0 3,5-dinitrobenzotrifluoride 
• 402-07-3 1-bromo-2-methoxy-4-(trifluoromethyl)benzene 
• 7664-41-7 ammonia 
• 328-79-0 1-methoxy-3-nitro-5-trifluoromethyl-benzene 

Downstream Products

• 62606-09-1 (3-Methoxy-5-trifluoromethyl-phenyl)-(2,4,6-trinitro-phenyl)-amine 
• 943722-82-5 C₁₇H₂₂F₃NO₂ 
• 315-15-1 2-amino-6-hydroxy-4-trifluoromethyl-benzoic acid 
• 320777-47-7 2-[(3-methoxy-5-(trifluoromethyl) phenyl)amino]phenylacetic Acid 
• 248929-69-3 (2RS,3R)-3-Amino-4-cyclohexyl-2-hydroxy-N-(3-methoxy-5-(trifluoromethyl)phenyl)butanamide Hydrochloride 
• 1030026-19-7 3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}-15α-(4-morpholin-4-yl-4-oxobutyl)estra-1(10),2,4-trien-17-one 
• 850798-32-2 N,N'-bis-(3-methoxy-5-trifuoromethyl-phenyl)-malonamide 
• 627527-23-5 1-bromo-3-methoxy-5-(trifluoromethyl)benzene 
• 1274887-23-8 C₂₅H₂₅F₃N₄O₂ 
• 1274885-07-2 N-[3-methoxy-5-(trifluoromethyl)phenyl]-1-(2-methyl-4-pyridinyl)-5-[(phenylmethoxy)methyl]-1H-pyrazol-3-amine 
• 1274885-08-3 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-methanol 
• 1274885-09-4 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile 
• 1274885-10-7 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetic acid methyl ester 
• 1274885-12-9 N-(cyclopropylmethyl)-3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetamide 

Relevant articles and documents

2,3-DIHYDROIMIDAZO[1 ,2-c] PYRIMIDIN-5(1 H)-ONE COMPOUNDS USE AS LP-PLA2 INHIBITORS

Disclosed are 2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one compounds that inhibit Lp-PLA2, processes for their preparation, compositions containing them and their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

QUINOLINE UROTENSIN-II RECEPTOR ANTAGONISTS

Provided are compounds that are modulators of urotensin-II receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, provided are methods for treating or ameliorating diseases associated with modulation of urotensin-II receptor activity.

Palladium-catalyzed silane/siloxane reductions in the one-pot conversion of nitro compounds into their amines, hydroxylamines, amides, sulfonamides, and carbamates

A combination of palladium(II) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS) facilitates the room-temperature reduction of aromatic nitro compounds to anilines. These reactions tend to be quick (30 min), high-yielding, and tolerate a range of other functional groups. Replacement of PMHS/KF with triethylsilane allows for the reduction of aliphatic nitro compounds to their corresponding hydroxylamines. Depending on the substrate, both conditions can allow for the in situ conversion of the product amines into amides, sulfonamides, and carbamates. Georg Thieme Verlag Stuttgart.