(R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide hydrochloride

Base Information

Chemical Name:(R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide hydrochloride
CAS No.:1433993-23-7
Molecular Formula:C₁₆H₁₇NO₂S*ClH
Molecular Weight:323.843
Hs Code.:

Synonyms:(R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide hydrochloride

Chemical Property:

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Technology Process of (R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide hydrochloride

There total 12 articles about (R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1433993-22-6
(R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 1,1-dioxide

: 1433993-23-7
(R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃;

Reference yield:

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 1433993-23-7
(R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: dichloromethane / 0 - 20 °C

2.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 4 h / 60 °C

4.1: lithium hydroxide monohydrate / tetrahydrofuran / 55 °C

5.1: hydrogenchloride / methanol; ethyl acetate / 1 h / 20 °C

6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 30 h / Reflux

8.1: dichloromethane / 0 - 20 °C

9.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

10.1: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; lithium hydroxide monohydrate; carbon tetrabromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; HATU; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 141595-88-2
(R)-tert-butyl (1-bromo-3-phenylpropan-2-yl)carbamate

: 1433993-23-7
(R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 4 h / 60 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran / 55 °C

3.1: hydrogenchloride / methanol; ethyl acetate / 1 h / 20 °C

4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 30 h / Reflux

6.1: dichloromethane / 0 - 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

8.1: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; lithium hydroxide monohydrate; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;