(R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 1,1-dioxide

Base Information

Chemical Name:(R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 1,1-dioxide
CAS No.:1433993-22-6
Molecular Formula:C₂₁H₂₅NO₄S
Molecular Weight:387.5
Hs Code.:

Synonyms:(R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 1,1-dioxide

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Chemical Property of (R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 1,1-dioxide

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Technology Process of (R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 1,1-dioxide

There total 11 articles about (R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1433993-21-5
(R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate

: 1433993-22-6
(R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 1,1-dioxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 1433993-22-6
(R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 1,1-dioxide

Guidance literature:: Multi-step reaction with 9 steps

1.1: dichloromethane / 0 - 20 °C

2.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 4 h / 60 °C

4.1: lithium hydroxide monohydrate / tetrahydrofuran / 55 °C

5.1: hydrogenchloride / methanol; ethyl acetate / 1 h / 20 °C

6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 30 h / Reflux

8.1: dichloromethane / 0 - 20 °C

9.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; lithium hydroxide monohydrate; carbon tetrabromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; HATU; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 141595-88-2
(R)-tert-butyl (1-bromo-3-phenylpropan-2-yl)carbamate

: 1433993-22-6
(R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 1,1-dioxide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 4 h / 60 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran / 55 °C

3.1: hydrogenchloride / methanol; ethyl acetate / 1 h / 20 °C

4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 30 h / Reflux

6.1: dichloromethane / 0 - 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; lithium hydroxide monohydrate; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;