(7R,8R)-7-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-(2-[1,3]dioxolan-2-ylethyl)-1,4-dioxaspiro[4,5]decane

Base Information

Chemical Name:(7R,8R)-7-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-(2-[1,3]dioxolan-2-ylethyl)-1,4-dioxaspiro[4,5]decane
CAS No.:866398-07-4
Molecular Formula:C₂₉H₄₆O₅
Molecular Weight:474.681
Hs Code.:

Synonyms:(7R,8R)-7-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-(2-[1,3]dioxolan-2-ylethyl)-1,4-dioxaspiro[4,5]decane

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Chemical Property of (7R,8R)-7-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-(2-[1,3]dioxolan-2-ylethyl)-1,4-dioxaspiro[4,5]decane

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Technology Process of (7R,8R)-7-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-(2-[1,3]dioxolan-2-ylethyl)-1,4-dioxaspiro[4,5]decane

There total 10 articles about (7R,8R)-7-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-(2-[1,3]dioxolan-2-ylethyl)-1,4-dioxaspiro[4,5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 866398-05-2
(1R,4R,5R,8S)-4-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-methoxymethoxybicyclo[3.3.1]non-3-en-2-one

: 107-21-1
ethylene glycol

: 866398-07-4
(7R,8R)-7-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-(2-[1,3]dioxolan-2-ylethyl)-1,4-dioxaspiro[4,5]decane

Guidance literature:: With toluene-4-sulfonic acid; In xylene; for 1h; Heating;
DOI:10.1021/ol051570c

Reference yield:

: 866398-19-8
trifluoromethanesulfonic acid 3-(1,1-dimethylheptyl)-5-methoxyphenyl ester

: 866398-07-4
(7R,8R)-7-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-(2-[1,3]dioxolan-2-ylethyl)-1,4-dioxaspiro[4,5]decane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / H₂; Et₃N / Pd/C / methanol / 120 h / 20 °C

2.1: 87 percent / Br₂; AcOH / 4 h / 20 °C

3.1: Mg; I₂ / tetrahydrofuran / 1.33 h / Heating

3.2: HMPA; CuBr*Me₂S / tetrahydrofuran / 2 h / -78 °C

4.1: 638 mg / TBAF / tetrahydrofuran / 0.5 h / 20 °C

5.1: 88 percent / TsOH / xylene / 1 h / Heating

With tetrabutyl ammonium fluoride; hydrogen; bromine; iodine; toluene-4-sulfonic acid; magnesium; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; xylene;
DOI:10.1021/ol051570c

Reference yield:

: 866398-16-5
trifluoromethanesulfonic acid 4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl ester

: 866398-07-4
(7R,8R)-7-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-(2-[1,3]dioxolan-2-ylethyl)-1,4-dioxaspiro[4,5]decane

Guidance literature:: Multi-step reaction with 8 steps

1.1: 82 percent / H₂; Et₃N / Pd/C / methanol / 192 h / 20 °C / atmospheric pressure

2.1: 68 percent / 1-propanethiol; NaH / dimethylformamide / 20 h / 120 °C

3.1: 87 percent / 2,4,6-collidine / CH₂Cl₂ / 24 h / 0 °C

4.1: 100 percent / H₂; Et₃N / Pd/C / methanol / 120 h / 20 °C

5.1: 87 percent / Br₂; AcOH / 4 h / 20 °C

6.1: Mg; I₂ / tetrahydrofuran / 1.33 h / Heating

6.2: HMPA; CuBr*Me₂S / tetrahydrofuran / 2 h / -78 °C

7.1: 638 mg / TBAF / tetrahydrofuran / 0.5 h / 20 °C

8.1: 88 percent / TsOH / xylene / 1 h / Heating

With 2,4,6-trimethyl-pyridine; 1-thiopropane; tetrabutyl ammonium fluoride; hydrogen; bromine; iodine; sodium hydride; toluene-4-sulfonic acid; magnesium; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; xylene;
DOI:10.1021/ol051570c