1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)-(4S)-(phenylmethyl)tetrahydro-1H-1-imidazolecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)-(4S)-(phenylmethyl)tetrahydro-1H-1-imidazolecarboxylate
CAS No.:1004755-03-6
Molecular Formula:C₂₉H₃₀Cl₂N₂O₃
Molecular Weight:525.475
Hs Code.:

Synonyms:1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)-(4S)-(phenylmethyl)tetrahydro-1H-1-imidazolecarboxylate

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Chemical Property of 1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)-(4S)-(phenylmethyl)tetrahydro-1H-1-imidazolecarboxylate

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Technology Process of 1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)-(4S)-(phenylmethyl)tetrahydro-1H-1-imidazolecarboxylate

There total 1 articles about 1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)-(4S)-(phenylmethyl)tetrahydro-1H-1-imidazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1004755-00-3,1149765-08-1
1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate

: 100-39-0
benzyl bromide

: 1004755-03-6
1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)-(4S)-(phenylmethyl)tetrahydro-1H-1-imidazolecarboxylate

Guidance literature:: 1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate; With n-butyllithium; diisopropylamine; 1,10-Phenanthroline; In tetrahydrofuran; hexane; at -20 - -15 ℃; for 1h;

benzyl bromide; In tetrahydrofuran; hexane; at -20 - 0 ℃; for 21h; Product distribution / selectivity;

Reference yield:

: 1004755-03-6
1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)-(4S)-(phenylmethyl)tetrahydro-1H-1-imidazolecarboxylate

: 74-88-4
methyl iodide

: 1158247-46-1
1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-(4R)-methyl-5-oxo-3-((1'R)-phenylethyl)-4-(phenylmethyl)tetrahydro-1H-imidazole-1-carboxylate

Guidance literature:: 1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)-(4S)-(phenylmethyl)tetrahydro-1H-1-imidazolecarboxylate; With n-butyllithium; diisopropylamine; 1,10-Phenanthroline; In tetrahydrofuran; hexane; at -20 ℃; for 1h;

methyl iodide; In tetrahydrofuran; hexane; at -20 - 0 ℃; for 17h;

Reference yield:

: 1004755-03-6
1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)-(4S)-(phenylmethyl)tetrahydro-1H-1-imidazolecarboxylate

: 1004755-04-7
3-phenyl-(2S)-[(1'R)-phenylethylamino]propionic acid

Guidance literature:: 1,1-dimethylethyl (2R)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)-(4S)-(phenylmethyl)tetrahydro-1H-1-imidazolecarboxylate; With ethanol; sulfuric acid; water; at 60 ℃; for 24h;

With sulfuric acid; water; at 120 - 130 ℃; for 16.5h; Product distribution / selectivity;