ethyl 3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]propanoate

Base Information

Chemical Name:ethyl 3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]propanoate
CAS No.:851578-39-7
Molecular Formula:C₂₈H₄₀N₂O₄
Molecular Weight:468.637
Hs Code.:

Synonyms:ethyl 3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]propanoate

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Chemical Property of ethyl 3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]propanoate

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Technology Process of ethyl 3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]propanoate

There total 10 articles about ethyl 3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 851577-56-5
tert-butyl {[5-formyl-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

: 851578-39-7
ethyl 3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]propanoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 1h;

Reference yield: 68.0%

: 851577-57-6
ethyl (2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoate

: 851578-39-7
ethyl 3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]propanoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 1h; under 3750.38 Torr;
DOI:10.1021/jm101236h

Reference yield:

: 907611-08-9
5-methyl-2-[(4-methylphenyl)methylidene]-3-oxohexanenitrile

: 851578-39-7
ethyl 3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / 1 h / 80 °C

2.1: ammonium cerium (IV) nitrate / water; acetone

3.1: ammonia; hydrogen / tetrahydrofuran; methanol / 3750.38 Torr

4.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

4.2: 15 h / 0 - 20 °C

5.1: sodium hydroxide / tetrahydrofuran / 20 °C

6.1: manganese(IV) oxide / tetrahydrofuran / 19 h / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

7.2: 0.75 h / 20 °C

8.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 20 °C / 3750.38 Torr

With manganese(IV) oxide; ammonium cerium (IV) nitrate; palladium 10% on activated carbon; ammonia; hydrogen; sodium hydride; diisobutylaluminium hydride; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; acetone; toluene; mineral oil; 7.1: Horner-Wadsworth-Emmons olefination / 7.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm101236h