tert-butyl {[5-formyl-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

Base Information

Chemical Name:tert-butyl {[5-formyl-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate
CAS No.:851577-56-5
Molecular Formula:C₂₄H₃₂N₂O₃
Molecular Weight:396.53
Hs Code.:

Synonyms:tert-butyl {[5-formyl-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

Suppliers and Price of tert-butyl {[5-formyl-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl {[5-formyl-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl {[5-formyl-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

There total 9 articles about tert-butyl {[5-formyl-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 851577-49-6
tert-butyl {[5-(hydroxymethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

: 851577-56-5
tert-butyl {[5-formyl-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

Guidance literature:: tert-butyl {[5-(hydroxymethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate; With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate; sodium thiosulfate; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2017.05.048

Reference yield:

: 851577-38-3
methyl 5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridine-3-carboxylate

: 851577-56-5
tert-butyl {[5-formyl-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

1.2: 15 h / 0 - 20 °C

2.1: sodium hydroxide / tetrahydrofuran / 20 °C

3.1: manganese(IV) oxide / tetrahydrofuran / 19 h / 20 °C

With manganese(IV) oxide; diisobutylaluminium hydride; sodium hydroxide; In tetrahydrofuran; toluene;
DOI:10.1021/jm101236h

Reference yield:

: 907611-08-9
5-methyl-2-[(4-methylphenyl)methylidene]-3-oxohexanenitrile

: 851577-56-5
tert-butyl {[5-formyl-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / 1 h / 80 °C

2.1: ammonium cerium (IV) nitrate / water; acetone

3.1: ammonia; hydrogen / tetrahydrofuran; methanol / 3750.38 Torr

4.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

4.2: 15 h / 0 - 20 °C

5.1: sodium hydroxide / tetrahydrofuran / 20 °C

6.1: manganese(IV) oxide / tetrahydrofuran / 19 h / 20 °C

With manganese(IV) oxide; ammonium cerium (IV) nitrate; ammonia; hydrogen; diisobutylaluminium hydride; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; water; acetone; toluene;
DOI:10.1021/jm101236h