phenyl 2-(7-amino-2,3,4,5-tetrahydro-11H-benzo[b]azepin-1-yl)ethyl(methyl)carbamate

Base Information

• Chemical Name: phenyl 2-(7-amino-2,3,4,5-tetrahydro-11H-benzo[b]azepin-1-yl)ethyl(methyl)carbamate
• CAS No.: 1063407-96-4
• Molecular Formula: C₂₀H₂₅N₃O₂
• Molecular Weight: 339.437

Synonyms:phenyl 2-(7-amino-2,3,4,5-tetrahydro-11H-benzo[b]azepin-1-yl)ethyl(methyl)carbamate

Chemical Property of phenyl 2-(7-amino-2,3,4,5-tetrahydro-11H-benzo[b]azepin-1-yl)ethyl(methyl)carbamate

Chemical Property:

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Technology Process of phenyl 2-(7-amino-2,3,4,5-tetrahydro-11H-benzo[b]azepin-1-yl)ethyl(methyl)carbamate

There total 4 articles about phenyl 2-(7-amino-2,3,4,5-tetrahydro-11H-benzo[b]azepin-1-yl)ethyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

phenyl methyl(2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate (1063407-94-2) → phenyl 2-(7-amino-2,3,4,5-tetrahydro-11H-benzo[b]azepin-1-yl)ethyl(methyl)carbamate (1063407-96-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃;

DOI:10.1016/j.bmcl.2012.02.004

Reference yield:

N,N-dimethyl-2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine (1063407-93-1) → phenyl 2-(7-amino-2,3,4,5-tetrahydro-11H-benzo[b]azepin-1-yl)ethyl(methyl)carbamate (1063407-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: palladium on activated charcoal; hydrogen / ethanol / 20 °C

With palladium on activated charcoal; hydrogen; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2012.02.004

Reference yield:

1-(2-(dimethylamino)ethyl)-7-nitro-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one (1063407-23-7) → phenyl 2-(7-amino-2,3,4,5-tetrahydro-11H-benzo[b]azepin-1-yl)ethyl(methyl)carbamate (1063407-96-4)

Guidance literature:

Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / Reflux

2: dichloromethane / 20 °C

3: palladium on activated charcoal; hydrogen / ethanol / 20 °C

With borane-THF; palladium on activated charcoal; hydrogen; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2012.02.004

upstream raw materials:

phenyl methyl(2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate

N,N-dimethyl-2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine

1-(2-(dimethylamino)ethyl)-7-nitro-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one

1,3,4,5-Tetrahydro-7-nitro-2H-benzazepin-2-on

Downstream raw materials:

phenyl-methyl(2-(7-(thiophene-2-carboximidamido)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate

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