phenyl methyl(2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate

Base Information

• Chemical Name: phenyl methyl(2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate
• CAS No.: 1063407-94-2
• Molecular Formula: C₂₀H₂₃N₃O₄
• Molecular Weight: 369.42

Synonyms:phenyl methyl(2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate

Chemical Property of phenyl methyl(2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate

Chemical Property:

Purity/Quality:

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Technology Process of phenyl methyl(2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate

There total 3 articles about phenyl methyl(2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N,N-dimethyl-2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine (1063407-93-1) + phenyl chloroformate (1885-14-9) → phenyl methyl(2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate (1063407-94-2)

Guidance literature:

N,N-dimethyl-2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine; phenyl chloroformate; at 20 ℃; for 21h;

With sodium hydroxide; water; In dichloromethane;

Reference yield:

1-(2-(dimethylamino)ethyl)-7-nitro-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one (1063407-23-7) → phenyl methyl(2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate (1063407-94-2)

Guidance literature:

Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / Reflux

2: dichloromethane / 20 °C

With borane-THF; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2012.02.004

Reference yield:

1,3,4,5-Tetrahydro-7-nitro-2H-benzazepin-2-on (22246-45-3) → phenyl methyl(2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate (1063407-94-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide

2: borane-THF / tetrahydrofuran / Reflux

3: dichloromethane / 20 °C

With borane-THF; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.02.004

upstream raw materials:

N,N-dimethyl-2-(7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine

phenyl chloroformate

1-(2-(dimethylamino)ethyl)-7-nitro-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one

1,3,4,5-Tetrahydro-7-nitro-2H-benzazepin-2-on

Downstream raw materials:

phenyl 2-(7-amino-2,3,4,5-tetrahydro-11H-benzo[b]azepin-1-yl)ethyl(methyl)carbamate

phenyl-methyl(2-(7-(thiophene-2-carboximidamido)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethyl)carbamate

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