4-methyl-3-(2-fluoro-3-nitrobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Base Information

Chemical Name:4-methyl-3-(2-fluoro-3-nitrobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran
CAS No.:946126-04-1
Molecular Formula:C₂₁H₁₄FN₃O₅
Molecular Weight:407.358
Hs Code.:

Synonyms:4-methyl-3-(2-fluoro-3-nitrobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

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Chemical Property of 4-methyl-3-(2-fluoro-3-nitrobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

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Technology Process of 4-methyl-3-(2-fluoro-3-nitrobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

There total 10 articles about 4-methyl-3-(2-fluoro-3-nitrobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 946130-13-8
3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran

: 4595-60-2
2-bromopyrimidine

: 946126-04-1
4-methyl-3-(2-fluoro-3-nitrobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Reference yield: 57.0%

: 946126-04-1
4-methyl-3-(2-fluoro-3-nitrobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Guidance literature:

Reference yield:

: 437-86-5
2-fluoro-3-nitrotoluene

: 946126-04-1
4-methyl-3-(2-fluoro-3-nitrobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Guidance literature:: Multi-step reaction with 4 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 5 h / Reflux; Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 20 °C

3.1: sulfuric acid / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; sulfuric acid; sodium hydride; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;