437-86-5

Basic information

• Product Name: 2-Fluoro-3-nitrotoluene
• Synonyms: 2-FLUORO-3-NITROTOLUENE;2-Fluoro-3-nitrotluene;2-Fluoro-3-maethylnitrobenzene;2-FLUORO-1-METHYL-3-NITROBENZENE;2-fluoro-3-methylnitrobenzene;2-fluoro-3-Nitrotoluol;2-Fluoro-3-methylnitrobenzene, 2-Fluoro-1-methyl-3-nitrobenzene
• CAS NO: 437-86-5
• Molecular Formula: C₇H₆FNO₂
• Molecular Weight: 155.13
• EINECS: 202-670-1
• Product Categories: Fluorin-contained toluene series;Aromatic Hydrocarbons (substituted) & Derivatives;Halogen toluene;Fluorinated benzene series
• Mol File: 437-86-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 19℃
• Boiling Point: 111℃/12mm
• Flash Point: 98°(208°F)
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.276
• Vapor Pressure: 0.0641mmHg at 25°C
• Refractive Index: 1.5290
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Fluoro-3-nitrotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-3-nitrotoluene(437-86-5)
• EPA Substance Registry System: 2-Fluoro-3-nitrotoluene(437-86-5)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34-36/37/38-20/22
• Safety Statements: 26-36/37/39-45-36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 437-86-5(Hazardous Substances Data)

Usage

Chemical Properties

Clear light yellow to yellow liquid

InChI:InChI=1/C7H6FNO2/c1-5-3-2-4-6(7(5)8)9(10)11/h2-4H,1H3

Upstream product

• 13073-29-5 2-methyl-6-nitrophenol 
• 95-48-7 ortho-cresol 
• 762287-58-1 (2-fluoro-3-methylphenyl)boronic acid 
• 3970-40-9 2-chloro-3-nitrotoluene 
• 95-52-3 2-Fluorotoluene 

Downstream Products

• 356072-51-0 1-Ethoxycarbonyl-4-[(2-methyl-6-nitrophenyl)amino]piperidine 
• 946125-65-1 1-(bromomethyl)-2-fluoro-3- nitrobenzene 
• 946130-07-0 2-(2-fluoro-3-nitrobenzyl)-3-oxo-butyric acid ethyl ester 
• 946126-97-2 2-oxo-2H-3-(2-fluoro-3-aminobenzyl)-4-methyl-7-hydroxy-1-benzopyran 
• 946126-42-7 4-methyl-3-(2-fluoro-3-aminobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran 
• 946128-76-3 3-{2-fluoro-3-(methylaminosulfonyl)aminobenzyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran 
• 946126-61-0 4-methyl-3-(2-fluoro-3-aminobenzyl)-7-(thiazol-2-yloxy)-2-oxo-2H-1-benzopyran 
• 1195767-92-0 N-{3-[2-(1-amino-1-methylethyl)-5-(2-methyl-4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide 
• 1195767-56-6 N-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(4-morpholinyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}methyl)cyclopentanecarboxamide 
• 1195769-66-4 1,1-dimethylethyl 4-[5-(2-amino-4-pyrimidinyl)-4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-2-yl]-4-methyl-1-piperidinecarboxylate 
• 1195769-64-2 1,1-dimethylethyl 4-[5-(2-chloro-4-pyrimidinyl)-4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-2-yl]-4-methyl-1-piperidinecarboxylate 
• 1195769-74-4 1,1-dimethylethyl 4-[5-(2-amino-4-pyrimidinyl)-4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate 
• 1195767-57-7 N-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(4-morpholinyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}methyl)-2-methylpropanamide 
• 1195769-72-2 1,1-dimethylethyl 4-[5-(2-chloro-4-pyrimidinyl)-4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate 

Relevant articles and documents

Synthesis method of 2-fluoro-3-nitrobenzoic acid intermediate raw material

The invention discloses a synthesis method of a 2-fluoro-3-nitrobenzoic acid intermediate raw material. The invention provides a novel synthesis route, and an important medical intermediate can be rapidly and conveniently prepared from cheap and easily available raw materials. The process method comprises the following steps: starting from o-methylphenol, carrying out nitration reaction to selectively generate a key intermediate 2-methyl-6-nitrophenol, carrying out hydroxyl chlorination to generate 2-chloro-3-nitrotoluene, then carrying out fluorination reaction to generate 2-fluoro-3-nitrotoluene, and finally oxidizing methyl under the action of an oxidant to generate 2-fluoro-3-nitrobenzoic acid. The method is not only high in yield, but also suitable for large-scale production.

p27 PROTEIN INDUCER

The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G 1 , G 2 , G 3 and G 8 are each independently selected from -N= etc., Ring G 6 is selected from divalent aryl etc., A is selected from amino etc., G 4 is selected from oxygen etc., G 5 is selected from oxygen etc., G 7 is selected from -CH 2 - etc., and R 2 is selected from C 1-6 alkyl etc.

p27 PROTEIN INDUCER

The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from -N= etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from -CH2- etc., and R2 is selected from C1-6 alkyl etc.