946130-13-8Relevant articles and documents
Hybrids of MEK inhibitor and NO donor as multitarget antitumor drugs
Liang, Lei,Niu, Yan,Peng, Yihong,Wang, Chao,Wang, Han,Xi, Dandan,Xu, Fengrong,Xu, Ping
, (2020)
A series of hybrids of MEK inhibitor and nitric oxide donor have been designed and synthesized. Compound 18h [4-(3-((3-(2-fluoro-3-((N-methylsulfamoyl)amino)benzyl)-4-methyl-2-oxo-2H-chromen-7-yl)oxy) propoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide]
p27 PROTEIN INDUCER
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Paragraph 0779-0783, (2016/10/08)
The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G 1 , G 2 , G 3 and G 8 are each independently selected from -N= etc., Ring G 6 is selected from divalent aryl etc., A is selected from amino etc., G 4 is selected from oxygen etc., G 5 is selected from oxygen etc., G 7 is selected from -CH 2 - etc., and R 2 is selected from C 1-6 alkyl etc.
Fluorine scanning by nonselective fluorination: Enhancing Raf/MEK inhibition while keeping physicochemical properties
Hyohdoh, Ikumi,Furuichi, Noriyuki,Aoki, Toshihiro,Itezono, Yoshiko,Shirai, Haruyoshi,Ozawa, Sawako,Watanabe, Fumio,Matsushita, Masayuki,Sakaitani, Masahiro,Ho, Pil-Su,Takanashi, Kenji,Harada, Naoki,Tomii, Yasushi,Yoshinari, Kiyoshi,Ori, Kazutomo,Tabo, Mitsuyasu,Aoki, Yuko,Shimma, Nobuo,Iikura, Hitoshi
supporting information, p. 1059 - 1063 (2013/12/04)
A facile methodology effective in obtaining a set of compounds monofluorinated at various positions (fluorine scan) by chemical synthesis is reported. Direct and nonselective fluorination reactions of our lead compound 1a and key intermediate 2a worked efficiently to afford a total of six monofluorinated derivatives. All of the derivatives kept their physicochemical properties compared with the lead 1a and one of them had enhanced Raf/MEK inhibitory activity. Keeping physicochemical properties could be considered a benefit of monofluorinated derivatives compared with chlorinated derivatives, iodinated derivatives, methylated derivatives, etc. This key finding led to the identification of compound 14d, which had potent tumor growth inhibition in a xenograft model, excellent PK profiles in three animal species, and no critical toxicity.