N,N-Dicyclohexyl-C-[(1R,2S,4S)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-dec-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

Base Information

Chemical Name:N,N-Dicyclohexyl-C-[(1R,2S,4S)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-dec-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide
CAS No.:104926-27-4
Molecular Formula:C₃₅H₆₅NO₄SSi
Molecular Weight:624.057
Hs Code.:

Synonyms:N,N-Dicyclohexyl-C-[(1R,2S,4S)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-dec-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

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Chemical Property of N,N-Dicyclohexyl-C-[(1R,2S,4S)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-dec-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

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Technology Process of N,N-Dicyclohexyl-C-[(1R,2S,4S)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-dec-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

There total 1 articles about N,N-Dicyclohexyl-C-[(1R,2S,4S)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-dec-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 96864-09-4
Decanoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: 104926-27-4
N,N-Dicyclohexyl-C-[(1R,2S,4S)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-dec-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

Guidance literature:: With n-butyllithium; diisopropylamine; Multistep reaction; 1.) THF, hexane, - 78 deg C 2.) -78 deg C, 1 h.;

Reference yield: 68.0%

: 104926-27-4
N,N-Dicyclohexyl-C-[(1R,2S,4S)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-dec-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

: 104926-28-5
(R)-2-Bromo-decanoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: (S)-2-Bromo-decanoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: With N-Bromosuccinimide; In tetrahydrofuran; Yields of byproduct given. Title compound not separated from byproducts; 1.) -78 to 0 deg C, 3 h 2.) 0 deg C, 30 min. d.e. 96 percent;

Reference yield:

: 104926-27-4
N,N-Dicyclohexyl-C-[(1R,2S,4S)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-dec-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

: 99295-72-4
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-hydroxybicyclo[2.2.1]heptane-1-methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) NEt₃*HF / 1.) CH₂Cl₂, -15 deg C, 15 min, 20 deg C, 30 min; 2.) 20 deg C, 4 h

2: 100 percent / K₂CO₃ / methanol / 20 h / 20 °C

With potassium carbonate; triethylamine hydrofluoride; In methanol;
DOI:10.1002/hlca.19850680127