α-(tert-butyloxycarbonylamino)-N^α-(benzyloxycarbonyl)glycine methyl ester

Base Information

Chemical Name:α-(tert-butyloxycarbonylamino)-N^α-(benzyloxycarbonyl)glycine methyl ester
CAS No.:103711-24-6
Molecular Formula:C₁₆H₂₂N₂O₆
Molecular Weight:338.36
Hs Code.:

α-(tert-butyloxycarbonylamino)-N<sup>α</sup>-(benzyloxycarbonyl)glycine methyl ester

Synonyms:α-(tert-butyloxycarbonylamino)-N^α-(benzyloxycarbonyl)glycine methyl ester

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Chemical Property of α-(tert-butyloxycarbonylamino)-N^α-(benzyloxycarbonyl)glycine methyl ester

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Technology Process of α-(tert-butyloxycarbonylamino)-N^α-(benzyloxycarbonyl)glycine methyl ester

There total 8 articles about α-(tert-butyloxycarbonylamino)-N^α-(benzyloxycarbonyl)glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 103711-23-5
α-<(tert-butyloxycarbonyl)amino>-N^α-(benzyloxycarbonyl)glycine

: 74-88-4
methyl iodide

: 103711-24-6
α-(tert-butyloxycarbonylamino)-N^α-(benzyloxycarbonyl)glycine methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 3h;
DOI:10.1021/jo00369a035

Reference yield: 56.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 160380-85-8
α-azido-N-(benzyloxycarbonyl)glycine methyl ester

: 103711-24-6
α-(tert-butyloxycarbonylamino)-N^α-(benzyloxycarbonyl)glycine methyl ester

Guidance literature:: With hydrogen; Lindlar's catalyst; In methanol; for 5h; under 750.06 Torr; Ambient temperature;
DOI:10.1055/s-1994-25592

Reference yield:

: 127357-38-4
N-(benzyloxycarbonyl)-α-hydroxy-glycine methyl ester

: 103711-24-6
α-(tert-butyloxycarbonylamino)-N^α-(benzyloxycarbonyl)glycine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Et₃N, diphenylphosphorylazide (DPPA) / tetrahydrofuran / 1.) -20 deg C, 3 h; 2.) -5 deg C, 15 h

2: 56 percent / H₂ / Lindlar catalyst / methanol / 5 h / 750.06 Torr / Ambient temperature

With diphenylphosphoranyl azide; hydrogen; triethylamine; Lindlar's catalyst; In tetrahydrofuran; methanol;
DOI:10.1055/s-1994-25592