127357-38-4

Basic information

• Product Name: methyl 2-(benzyloxycarbonylamino)-2-hydroxyacetate
• Synonyms: methyl 2-(benzyloxycarbonylamino)-2-hydroxyacetate
• CAS NO: 127357-38-4
• Molecular Formula: C₁₁H₁₃NO₅
• Molecular Weight: 239
• EINECS: -0
• Mol File: 127357-38-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 2-(benzyloxycarbonylamino)-2-hydroxyacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(benzyloxycarbonylamino)-2-hydroxyacetate(127357-38-4)
• EPA Substance Registry System: methyl 2-(benzyloxycarbonylamino)-2-hydroxyacetate(127357-38-4)

Safety Data

• Hazardous Substances Data: 127357-38-4(Hazardous Substances Data)

Usage

General Description

Methyl 2-(benzyloxycarbonylamino)-2-hydroxyacetate is a chemical compound with the molecular formula C11H13NO5. It is a derivative of glycine and has the appearance of a white to off-white solid. methyl 2-(benzyloxycarbonylamino)-2-hydroxyacetate is used in the synthesis of various pharmaceuticals, especially in the development of new drugs for the treatment of various diseases. It is also used as a reagent in organic synthesis, particularly in the preparation of peptides and other organic compounds. Methyl 2-(benzyloxycarbonylamino)-2-hydroxyacetate is an important intermediate in organic chemistry and has a wide range of applications in the pharmaceutical and chemical industries.

Upstream product

• 74-96-4 ethyl bromide 
• 64356-76-9 N-benzyloxycarbonyl α-chloro glycine methyl ester 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 593-60-2 Vinyl bromide 
• 2003-82-9 3-bromo-2-propyne 
• 922-68-9 Methyl glyoxylate 
• 621-84-1 O-benzyl carbamate 
• 32620-08-9 Z-1-bromobutene 
• 4333-56-6 cyclopropyl bromide 
• 109745-70-2 methyl glyoxylate methyl hemi-acetal 
• 79002-45-2 N-benzyloxycarbonyl-glycine 
• 149-73-5 trimethyl orthoformate 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 103-64-0 bromostyrene 

Downstream Products

• 64356-76-9 N-benzyloxycarbonyl α-chloro glycine methyl ester 
• 127382-97-2 methyl N-(benzyloxycarbonyl)-α-bromoglycinate 
• 160380-85-8 α-azido-N-(benzyloxycarbonyl)glycine methyl ester 
• 89525-23-5 methyl (Z)-2-((benzyloxycarbonyl)amino)-2-pentenoate 
• 100945-15-1 N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester 
• 142602-48-0 methyl 2-(((benzyloxy)carbonyl)amino)pent-2-enoate 
• 42726-78-3 methyl N-benzyloxycarbonyl-α-benzylthioglycinate 
• 103711-24-6 α-(tert-butyloxycarbonylamino)-N^α-(benzyloxycarbonyl)glycine methyl ester 
• 103711-23-5 α-<(tert-butyloxycarbonyl)amino>-N^α-(benzyloxycarbonyl)glycine 
• 88259-97-6 2-carbobenzyloxy-3-carbomethoxy-2-azabicyclo<2.2.1>heptane 
• 99940-87-1 2-carbobenzyloxy-3-carbomethoxy-2-azabicyclo<2.2.1>hept-5-ene 
• 127357-69-1 methyl 2-amino-N-(benzyloxycarbonyl)-3-butynoate 
• 119839-50-8 methyl 2-amino-N-(benzyloxycarbonyl)-3-pentynoate 
• 119839-48-4 methyl 2-amino-N-(benzyloxycarbonyl)-3-heptynoate 

Relevant articles and documents

NOVEL PEPTIDE DERIVATIVES AND USES THEREOF

The invention provides for novel peptide derivatives and compositions comprising the same. The invention further provides methods of treatment comprising administering novel peptide derivatives and/or compositions comprising the same.

Synthesis of differently protected α-aminoglycines and their peptide derivatives

Compatibly protected α-aminoglycine and di- and tripeptides containing it are prepared from the corresponding α-hydroxyglycines.

SYNTHESIS OF α-AMINO ACIDS WITH β,γ-UNSATURATED SIDE CHAINS

α-Amino acids with allenyl, vinyl and acetylenic side chains can be synthesized using non-enolate based strategies.The ester enolate-Claisen rearrangement applied to propargylic esters of N-protected α-amino acids is of limited utility since only poor yields of allenic product are obtained with the N-Boc glycine esters, the system which give the most reproducible results.However, α-allenyl-α-amino acids that are fully functionalized on the α-carbon are available through the agency of 4-allenyl-2-phenyloxazolones 4 ( obtained from propargyl esters of N-benzoyl protected amino acids via cyclization and Claisen rearrangement ) provided that Meerwein's reagent is used to facilitate hydrolysis of the benzamide function in 5.A variety of α-substituted glycinates, including those with α-vinyl and α-acetylenic functions, can be prepared using a two step sequence involving condensation of the cationic glycine synthon 22 with various organomagnesium reagents, followed by hydrolysis.