tris(2-(6-{1-[1-(benzyloxy)-2-oxo-1,2-dihydropyrimidin-4-yl]amino}octanamido)ethyl)amine

Base Information

Chemical Name:tris(2-(6-{1-[1-(benzyloxy)-2-oxo-1,2-dihydropyrimidin-4-yl]amino}octanamido)ethyl)amine
CAS No.:189497-34-5
Molecular Formula:C₆₃H₈₇N₁₃O₉
Molecular Weight:1170.47
Hs Code.:

Synonyms:tris(2-(6-{1-[1-(benzyloxy)-2-oxo-1,2-dihydropyrimidin-4-yl]amino}octanamido)ethyl)amine

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Chemical Property of tris(2-(6-{1-[1-(benzyloxy)-2-oxo-1,2-dihydropyrimidin-4-yl]amino}octanamido)ethyl)amine

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Technology Process of tris(2-(6-{1-[1-(benzyloxy)-2-oxo-1,2-dihydropyrimidin-4-yl]amino}octanamido)ethyl)amine

There total 6 articles about tris(2-(6-{1-[1-(benzyloxy)-2-oxo-1,2-dihydropyrimidin-4-yl]amino}octanamido)ethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 4097-89-6
2,2',2''-triaminotriethylamine

: 189497-28-7
4-[(7-carboxyheptyl)amino]-1-(benzyloxy)-2(1H)-pyrimidinone O-succinimide ester

: 189497-34-5
tris(2-(6-{1-[1-(benzyloxy)-2-oxo-1,2-dihydropyrimidin-4-yl]amino}octanamido)ethyl)amine

Guidance literature:: In N,N-dimethyl-formamide; at 38 ℃; for 48h;
DOI:10.1021/jo961901m

Reference yield:

: 2048-50-2
benzyloxyurea

: 189497-34-5
tris(2-(6-{1-[1-(benzyloxy)-2-oxo-1,2-dihydropyrimidin-4-yl]amino}octanamido)ethyl)amine

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / Na / ethanol / 1.) 20 deg C, 3 h, 2.) reflux, 17 h, 3.) 10 deg C, 4 h

2: 61 percent / POCl₃, Et₃N / acetonitrile / 24 h / Ambient temperature; pH ca.9

3: 60 percent / Et₃N / tetrahydrofuran / 44 h / Heating

4: 80 percent / NaOH / methanol / 15 h / Ambient temperature

5: 100 percent / WSC*HCl / dimethylformamide / 14 h / Ambient temperature

6: 71 percent / dimethylformamide / 48 h / 38 °C

With sodium hydroxide; WSC*HCl; sodium; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo961901m

Reference yield:

: 721-01-7
1-(benzyloxy)uracil

: 189497-34-5
tris(2-(6-{1-[1-(benzyloxy)-2-oxo-1,2-dihydropyrimidin-4-yl]amino}octanamido)ethyl)amine

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / POCl₃, Et₃N / acetonitrile / 24 h / Ambient temperature; pH ca.9

2: 60 percent / Et₃N / tetrahydrofuran / 44 h / Heating

3: 80 percent / NaOH / methanol / 15 h / Ambient temperature

4: 100 percent / WSC*HCl / dimethylformamide / 14 h / Ambient temperature

5: 71 percent / dimethylformamide / 48 h / 38 °C

With sodium hydroxide; WSC*HCl; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo961901m