2-azido-3-[3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester

Base Information

• Chemical Name: 2-azido-3-[3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester
• CAS No.: 470691-17-9
• Molecular Formula: C₁₉H₂₃N₅O₃S
• Molecular Weight: 401.489

Synonyms:2-azido-3-[3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester

Chemical Property of 2-azido-3-[3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester

Chemical Property:

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Technology Process of 2-azido-3-[3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester

There total 4 articles about 2-azido-3-[3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

ethyl-2-azidoacetate (637-81-0) + 3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazole-4-carbaldehyde (470691-11-3) → 2-azido-3-[3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester (470691-17-9)

Guidance literature:

With sodium; In ethanol; at 0 ℃;

DOI:10.1002/jhet.5570390221

Reference yield:

4-methoxybenzylamine hydrochloride (17061-61-9) → 2-azido-3-[3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester (470691-17-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / glacial acetic acid / butan-1-ol

2: 94 percent / aq. sodium hydroxide

3: 95 percent / manganese dioxide / CHCl₃ / Heating

4: 59 percent / sodium / ethanol / 0 °C

With manganese(IV) oxide; sodium hydroxide; sodium; acetic acid; In ethanol; chloroform; butan-1-ol;

DOI:10.1002/jhet.5570390221

Reference yield:

[2-mercapto-1-(4-methoxybenzyl)-1H-imidazol-5-yl]methanol (470690-99-4) → 2-azido-3-[3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester (470691-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / aq. sodium hydroxide

2: 95 percent / manganese dioxide / CHCl₃ / Heating

3: 59 percent / sodium / ethanol / 0 °C

With manganese(IV) oxide; sodium hydroxide; sodium; In ethanol; chloroform;

DOI:10.1002/jhet.5570390221

upstream raw materials:

ethyl-2-azidoacetate

3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazole-4-carbaldehyde

4-methoxybenzylamine hydrochloride

[2-mercapto-1-(4-methoxybenzyl)-1H-imidazol-5-yl]methanol

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