[2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL

Base Information

• Chemical Name: [2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL
• CAS No.: 470690-99-4
• Molecular Formula: C12H14N2O2S
• Molecular Weight: 250.31700
• Mol file: 470690-99-4.mol

Synonyms:[2-Mercapto-3-(4-methoxy-benzyl)-3H-imidazol-4-yl]-methanol;5-hydroxymethyl-2-mercapto-1-(4-methoxybenzyl)imidazole;

Chemical Property of [2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL

Chemical Property:

• Melting Point: 217 - 220 °C
• PSA: 86.08000
• LogP: 1.72100

Purity/Quality:

99% ^*data from raw suppliers

[2-Mercapto-1-(4-methoxybenzyl)-1H-imidazol-5-yl]methanol 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL

There total 2 articles about [2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,3-dihydroxyacetone dimer (62147-49-3) + potassium thioacyanate (333-20-0) + 4-methoxybenzylamine hydrochloride (17061-61-9) → [2-mercapto-1-(4-methoxybenzyl)-1H-imidazol-5-yl]methanol (470690-99-4)

Guidance literature:

With acetic acid; In water; acetonitrile; at 55 ℃; for 18h; Further Variations:; Solvents; Product distribution;

DOI:10.1002/jhet.5570400206

Reference yield: 74.0%

dihydroxyacetone (96-26-4,26776-70-5) + potassium thioacyanate (333-20-0) + 4-methoxybenzylamine hydrochloride (17061-61-9) → [2-mercapto-1-(4-methoxybenzyl)-1H-imidazol-5-yl]methanol (470690-99-4)

Guidance literature:

With acetic acid; In butan-1-ol;

DOI:10.1002/jhet.5570390221

Reference yield: 94.0%

[2-mercapto-1-(4-methoxybenzyl)-1H-imidazol-5-yl]methanol (470690-99-4) → [3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-methanol (470691-05-5)

Guidance literature:

With sodium hydroxide;

DOI:10.1002/jhet.5570390221

upstream raw materials:

dihydroxyacetone

potassium thioacyanate

4-methoxybenzylamine hydrochloride

1,3-dihydroxyacetone dimer

Downstream raw materials:

5-hydroxymethyl-1-(4-methoxybenzyl)-2-methylthioimidazole

[2-ethylsulfanyl-3-(4-methoxy-benzyl)-3H-imidazol-4-yl]-methanol

[3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-methanol

3-(4-methoxy-benzyl)-2-methylsulfanyl-3H-imidazole-4-carbaldehyde