9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-acetyl-β-D-xylofuranosyl>adenine

Base Information

Chemical Name:9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-acetyl-β-D-xylofuranosyl>adenine
CAS No.:131372-49-1
Molecular Formula:C₃₈H₄₅N₅O₆Si
Molecular Weight:695.891
Hs Code.:

Synonyms:9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-acetyl-β-D-xylofuranosyl>adenine

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Chemical Property of 9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-acetyl-β-D-xylofuranosyl>adenine

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Technology Process of 9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-acetyl-β-D-xylofuranosyl>adenine

There total 4 articles about 9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-acetyl-β-D-xylofuranosyl>adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 127-09-3
sodium acetate

: 131372-47-9
5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-(trifluoromethanesulfonyl)adenosine

: 131372-49-1
9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-acetyl-β-D-xylofuranosyl>adenine

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; for 14h; Ambient temperature;
DOI:10.1055/s-1990-27048

Reference yield:

: 69504-04-7
5'-O-(monomethoxytrityl)-2'-O-<(tert-butyl)dimethylsilyl>adenosine

: 131372-49-1
9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-acetyl-β-D-xylofuranosyl>adenine

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / DMAP, Et₃N / CH₂Cl₂ / 1) -40 to -20 deg C, 1 h, 2) rt, 2 h

2: 72 percent / HMPT (hexamethylphosphoric triamide) / 14 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; triethylamine; In dichloromethane;
DOI:10.1055/s-1990-27048

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 131372-49-1
9-<5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-O-acetyl-β-D-xylofuranosyl>adenine

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / pyridine, AgNO₃ / tetrahydrofuran / Ambient temperature

2: 91 percent / DMAP, Et₃N / CH₂Cl₂ / 1) -40 to -20 deg C, 1 h, 2) rt, 2 h

3: 72 percent / HMPT (hexamethylphosphoric triamide) / 14 h / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; silver nitrate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-1990-27048