Imidazo[1,2-a]pyridin-6-ylmethanamine

Base Information

• Chemical Name: Imidazo[1,2-a]pyridin-6-ylmethanamine
• CAS No.: 132213-03-7
• Molecular Formula: C8H9 N3
• Molecular Weight: 147.18
• Hs Code.: 2933990090
• European Community (EC) Number: 860-520-6
• ChEMBL ID: CHEMBL5218868
• DSSTox Substance ID: DTXSID50564324
• Wikidata: Q82449005
• Mol file: 132213-03-7.mol

Synonyms:132213-03-7;Imidazo[1,2-a]pyridin-6-ylmethanamine;Imidazo[1,2-a]pyridin-6-ylmethylamine;Imidazo[1,2-a]pyridine-6-methanamine;C-IMIDAZO[1,2-A]PYRIDIN-6-YL-METHYLAMINE;CHEMBL5218868;1-(IMIDAZO[1,2-A]PYRIDIN-6-YL)METHANAMINE;1-{IMIDAZO[1,2-A]PYRIDIN-6-YL}METHANAMINE;SCHEMBL6092812;DTXSID50564324;BDBM50607379;MFCD08435852;AKOS006345733;AB44926;6-(Aminomethyl)imidazo[1,2-a]pyridine;{imidazo[1,2-a]pyridin-6-yl}methanamine;CS-0085040;F14017;EN300-1241724;Imidazo[1,2-a]pyridin-6-ylmethylamine, AldrichCPR;W-205396

Chemical Property of Imidazo[1,2-a]pyridin-6-ylmethanamine

Chemical Property:

• Melting Point: 96.5-99
• Boiling Point: °Cat760mmHg
• PKA: 7.84±0.29(Predicted)
• Flash Point: °C
• PSA: 43.32000
• Density: 1.26g/cm³
• LogP: 1.49330
• Storage Temp.: 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 147.079647300
• Heavy Atom Count: 11
• Complexity: 137

Purity/Quality:

97% ^*data from raw suppliers

C-Imidazo[1,2-A]pyridin-6-yl-methylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,Xn
• Statements: 22

MSDS Files:

Useful:

• Canonical SMILES: C1=CC2=NC=CN2C=C1CN

Technology Process of Imidazo[1,2-a]pyridin-6-ylmethanamine

There total 7 articles about Imidazo[1,2-a]pyridin-6-ylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

imidazo[1,2-a]pyridine-6-carbonitrile (106850-34-4) → imidazo<1,2-a>pyridin-6-ylmethylamine (132213-03-7)

Guidance literature:

With ammonium hydroxide; hydrogen; In methanol; water; at 20 ℃;

Reference yield: 100.0%

→ imidazo<1,2-a>pyridin-6-ylmethylamine (132213-03-7)

Guidance literature:

With ammonia; hydrogen; In methanol; at 20 ℃; for 16h;

Reference yield:

6-aminonicotinonitrile (4214-73-7) → imidazo<1,2-a>pyridin-6-ylmethylamine (132213-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: water; ethanol / 4 h / Reflux

2: hydrogen; ammonia / ethanol / 2 h / 20 °C

With ammonia; hydrogen; In ethanol; water;

DOI:10.1021/jm500510f

upstream raw materials:

6-(hydroxymethyl)imidazo[1,2-a]pyridine

6-aminonicotinic amide

ethyl-6-amino-nicotinate

(6-amino-3-pyridinyl)methanol

Downstream raw materials:

6-(4-fluorophenyl)-1-(imidazo[1,2-a]pyridin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine

1-[4-(benzenesulfonyl)phenyl]-3-{imidazo[1,2-a]pyridin-6-ylmethyl}urea