3-fluoro-4-((3-(1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxoimidazolidin-1-yl)methyl)-N-(2-hydroxyethyl)-N-methylbenzamide

Base Information

Chemical Name:3-fluoro-4-((3-(1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxoimidazolidin-1-yl)methyl)-N-(2-hydroxyethyl)-N-methylbenzamide
CAS No.:1437800-70-8
Molecular Formula:C₂₅H₂₈F₅N₅O₃
Molecular Weight:541.521
Hs Code.:

Synonyms:3-fluoro-4-((3-(1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxoimidazolidin-1-yl)methyl)-N-(2-hydroxyethyl)-N-methylbenzamide

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Chemical Property of 3-fluoro-4-((3-(1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxoimidazolidin-1-yl)methyl)-N-(2-hydroxyethyl)-N-methylbenzamide

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Technology Process of 3-fluoro-4-((3-(1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxoimidazolidin-1-yl)methyl)-N-(2-hydroxyethyl)-N-methylbenzamide

There total 3 articles about 3-fluoro-4-((3-(1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxoimidazolidin-1-yl)methyl)-N-(2-hydroxyethyl)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.9%

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 1437801-39-2
3-fluoro-4-((3-(1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxoimidazolidin-1-yl)methyl)benzoic acid

: 1437800-70-8
3-fluoro-4-((3-(1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxoimidazolidin-1-yl)methyl)-N-(2-hydroxyethyl)-N-methylbenzamide

Guidance literature:: 3-fluoro-4-((3-(1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxoimidazolidin-1-yl)methyl)benzoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

(2-hydroxyethyl)(methyl)amine; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 89402-42-6
2,3-difluoro-5-(trifluoromethyl)pyridine

: 1437800-70-8
3-fluoro-4-((3-(1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxoimidazolidin-1-yl)methyl)-N-(2-hydroxyethyl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 20 °C

2.1: lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 1 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: methyl 3-fluoro-4-((2-oxo-3-(piperidin-4-yl)imidazolidin-1-yl)methyl)benzoate trifluoroacetate

: 1437800-70-8
3-fluoro-4-((3-(1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxoimidazolidin-1-yl)methyl)-N-(2-hydroxyethyl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 20 °C

2.1: lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 1 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;