Methyl-[1-(4-methyl-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine

Base Information

Chemical Name:Methyl-[1-(4-methyl-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine
CAS No.:73736-28-4
Molecular Formula:C₂₉H₃₄N₄
Molecular Weight:438.616
Hs Code.:

Synonyms:Methyl-[1-(4-methyl-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine

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Chemical Property of Methyl-[1-(4-methyl-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine

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Technology Process of Methyl-[1-(4-methyl-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine

There total 12 articles about Methyl-[1-(4-methyl-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39742-60-4
1-(2-phenylethyl)-4-piperidinone

: 73736-28-4
Methyl-[1-(4-methyl-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 10 percent Pd/C / methanol

2: ethanol / 25 °C

3: H₂, NH₃ / 10 percent Pd/C / methanol / 760 Torr / Ambient temperature

4: Hg/S

5: 1.) sodium hydride / 1.) dimethyl sulfoxide, benzene, 30 min, 2.) dimethyl sulfoxide, benzene, RT, overnight

With ammonia; hydrogen; sodium hydride; sulfur; mercury; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1021/jm00150a029

Reference yield:

: 2719-30-4
o-nitrophenylisothiocyanate

: 73736-28-4
Methyl-[1-(4-methyl-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / ethanol / Ambient temperature

2: 95 percent / H₂, ammonia / 10 percent Pd/C / methanol / 760 Torr / Ambient temperature

3: 84 percent / yellow HgO, sulfur / methanol / 2 h / Heating

4: 95 percent / 48 percent aq. hydrobromic acid / 2 h / 120 °C

5: sodium carbonate / dimethylformamide / 70 °C

6: 1.) sodium hydride / 1.) dimethyl sulfoxide, benzene, 30 min, 2.) dimethyl sulfoxide, benzene, RT, overnight

With ammonia; hydrogen bromide; hydrogen; sodium hydride; sodium carbonate; sulfur; mercury(II) oxide; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029

Reference yield:

: 73733-69-4
ethyl 4-(methylamino)piperidine-1-carboxylate

: 73736-28-4
Methyl-[1-(4-methyl-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / ethanol / Ambient temperature

2: 95 percent / H₂, ammonia / 10 percent Pd/C / methanol / 760 Torr / Ambient temperature

3: 84 percent / yellow HgO, sulfur / methanol / 2 h / Heating

4: 95 percent / 48 percent aq. hydrobromic acid / 2 h / 120 °C

5: sodium carbonate / dimethylformamide / 70 °C

6: 1.) sodium hydride / 1.) dimethyl sulfoxide, benzene, 30 min, 2.) dimethyl sulfoxide, benzene, RT, overnight

With ammonia; hydrogen bromide; hydrogen; sodium hydride; sodium carbonate; sulfur; mercury(II) oxide; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029