73733-69-4

Basic information

• Product Name: 1-CARBETHOXY-4-(METHYLAMINO)PIPERIDINE
• Synonyms: ETHYL 4-(METHYLAMINO)PIPERIDINE-1-CARBOXYLATE;ETHYL 4-(METHYLAMINO)-1-PIPERIDINECARBOXYLATE;1-CARBETHOXY-4-(METHYLAMINO)PIPERIDINE;1-ETHOXYCARBONYL-4-(METHYLAMINO)-PIPERIDINE;Ethyl 4-(N-methyl)aminopiperidine-1-carboxylate;1-ETHOXYCARBONYL-4-(METHYLAMINO)-PIPERIDINE 98%;1-Carbethoxy-N-methyl-4-piperidinamine
• CAS NO: 73733-69-4
• Molecular Formula: C₉H₁₈N₂O₂
• Molecular Weight: 186.25
• Product Categories: Piperidine
• Mol File: 73733-69-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 267.431 °C at 760 mmHg
• Flash Point: 115.538 °C
• Appearance: /
• Density: 1.051 g/cm³
• Storage Temp.: 2-8°C
• PKA: 10.18±0.20(Predicted)
• CAS DataBase Reference: 1-CARBETHOXY-4-(METHYLAMINO)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CARBETHOXY-4-(METHYLAMINO)PIPERIDINE(73733-69-4)
• EPA Substance Registry System: 1-CARBETHOXY-4-(METHYLAMINO)PIPERIDINE(73733-69-4)

Safety Data

• Hazardous Substances Data: 73733-69-4(Hazardous Substances Data)

Usage

General Description

1-CARBETHOXY-4-(METHYLAMINO)PIPERIDINE is a chemical compound with the molecular formula C12H22N2O2. It is a piperidine derivative that contains a carbethoxy group and a methylamino group. 1-CARBETHOXY-4-(METHYLAMINO)PIPERIDINE has been studied for its potential use in pharmaceuticals, particularly as a precursor for the synthesis of pharmaceutical drugs. It has also been investigated for its potential as an intermediate in organic synthesis. The chemical properties and potential applications of 1-CARBETHOXY-4-(METHYLAMINO)PIPERIDINE make it a valuable compound for research and development in the pharmaceutical and chemical industries.

Upstream product

• 593-51-1 methylamine hydrochloride 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 
• 74-89-5 methylamine 

Downstream Products

• 172023-47-1 1-(4-Fluoro-phenyl)-4-[4-(methyl-naphtho[1,2-d]thiazol-2-yl-amino)-piperidin-1-yl]-butan-1-one 
• 874536-47-7 C₁₇H₂₅N₃O₂S 
• 100239-78-9 (E)-ethyl 4-[methyl(3-phenyl-2-propenyl)amino]-1-piperidinecarboxylate ethanedioate 
• 144665-07-6 (-)-Lubeluzole 
• 144665-07-6 lubeluzole 
• 73736-22-8 [1-(2-Methoxy-benzyl)-1H-benzoimidazol-2-yl]-methyl-(1-phenethyl-piperidin-4-yl)-amine 
• 98245-04-6 [1-(2-Chloro-benzyl)-1H-benzoimidazol-2-yl]-methyl-(1-phenethyl-piperidin-4-yl)-amine 
• 73736-25-1 [1-(4-Methoxy-benzyl)-1H-benzoimidazol-2-yl]-methyl-(1-phenethyl-piperidin-4-yl)-amine 
• 98245-06-8 [1-(4-Bromo-benzyl)-1H-benzoimidazol-2-yl]-methyl-(1-phenethyl-piperidin-4-yl)-amine 
• 98245-05-7 [1-(4-Chloro-benzyl)-1H-benzoimidazol-2-yl]-methyl-(1-phenethyl-piperidin-4-yl)-amine 
• 75971-17-4 1-<(4-fluorophenyl)methyl>-N-methyl-N-<1-(2-phenylethyl)-4-piperidinyl>-1H-benzimidazol-2-amine 
• 73736-28-4 Methyl-[1-(4-methyl-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine 
• 98245-03-5 (1-Benzyl-1H-benzoimidazol-2-yl)-methyl-(1-phenethyl-piperidin-4-yl)-amine 
• 98245-02-4 (1-Butyl-1H-benzoimidazol-2-yl)-methyl-(1-phenethyl-piperidin-4-yl)-amine 

Relevant articles and documents

The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca2+/calmodulin-dependent kinase II

An affinity capillary electrophoresis (ACE) method to estimate apparent dissociation constants between bovine brain calmodulin (CaM) and non-peptidic ligands was developed. The method was validated reproducing the dissociation constants of a number of wel

Synthesis of N-methyl secondary amines

A diverse set of N-methyl secondary amines are obtained in high yields by an expedient reductive alkylation of commercially available methanolic methylamine.

New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines

The synthesis of a series N-(4-piperidinyl)-1H-benzimidazol-2-amines and the preliminary evaluation of their in vitro and in vivo antihistaminic activity are described. Cyclodesulfurization of (2-aminophenyl) thioureas with mercury(II) oxide resulted in 2-aminobenzimidazole intermediates, which were monoalkylated on the endo-nitrogen atom. After deprotection of the piperideine nitrogen atom with 48% aqueous hydrobromic acid solution, the title compounds were obtained by three different methods, viz. alkylation, reductive amination, or oxirane ring-opening reactions. The in vivo antihistaminic activity was evaluated by the compound 48/80 induced lethality test in rats and histamine-induced lethality test in guinea pigs after oral and/or subcutaneous administration. The duration of action, for a selected number of compounds, was studied in the guinea pig. The phenylethyl derivatives showed the most potent antihistamine properties after oral administration in both animal species.