(1R,2'R,1''R)-(4-methoxyphenyl){1-[1'-(1''-phenylethyl)aziridin-2'-yl]ethyl}amine

Base Information

Chemical Name:(1R,2'R,1''R)-(4-methoxyphenyl){1-[1'-(1''-phenylethyl)aziridin-2'-yl]ethyl}amine
CAS No.:694526-66-4
Molecular Formula:C₁₉H₂₄N₂O
Molecular Weight:296.412
Hs Code.:

Synonyms:(1R,2'R,1''R)-(4-methoxyphenyl){1-[1'-(1''-phenylethyl)aziridin-2'-yl]ethyl}amine

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Chemical Property of (1R,2'R,1''R)-(4-methoxyphenyl){1-[1'-(1''-phenylethyl)aziridin-2'-yl]ethyl}amine

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Technology Process of (1R,2'R,1''R)-(4-methoxyphenyl){1-[1'-(1''-phenylethyl)aziridin-2'-yl]ethyl}amine

There total 6 articles about (1R,2'R,1''R)-(4-methoxyphenyl){1-[1'-(1''-phenylethyl)aziridin-2'-yl]ethyl}amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 75-16-1
methylmagnesium bromide

: 854763-27-2
(p-methoxyphenyl)-{[1'(R)-α-methylbenzyl]aziridine-2(R)-ylmethylene}amine

: 694526-66-4
(1R,2'R,1''R)-(4-methoxyphenyl){1-[1'-(1''-phenylethyl)aziridin-2'-yl]ethyl}amine

Guidance literature:: With boron trifluoride diethyl etherate; In diethyl ether; at -10 ℃; for 3h;
DOI:10.1055/s-2004-815444 DOI:10.1016/j.tet.2005.07.064

Reference yield: 76.0%

: 917-54-4
methyllithium

: 854763-27-2
(p-methoxyphenyl)-{[1'(R)-α-methylbenzyl]aziridine-2(R)-ylmethylene}amine

: 694526-66-4
(1R,2'R,1''R)-(4-methoxyphenyl){1-[1'-(1''-phenylethyl)aziridin-2'-yl]ethyl}amine

Guidance literature:: With boron trifluoride diethyl etherate; In diethyl ether; at -78 ℃; for 5h;
DOI:10.1055/s-2004-815444 DOI:10.1016/j.tet.2005.07.064

Reference yield:

: 104-94-9
4-methoxy-aniline

: 694526-66-4
(1R,2'R,1''R)-(4-methoxyphenyl){1-[1'-(1''-phenylethyl)aziridin-2'-yl]ethyl}amine

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / anhydrous MgSO₄ / CH₂Cl₂ / 5 h / 20 °C

2: 76 percent / BF₃*Et₂O / diethyl ether / 5 h / -78 °C

With boron trifluoride diethyl etherate; magnesium sulfate; In diethyl ether; dichloromethane;
DOI:10.1016/j.tet.2005.07.064