1-ethyl 2-methyl 3-amino-4-<4-(benzyloxy)benzyl>-1H-pyrrole-1,2-dicarboxylate

Base Information

Chemical Name:1-ethyl 2-methyl 3-amino-4-<4-(benzyloxy)benzyl>-1H-pyrrole-1,2-dicarboxylate
CAS No.:1027413-96-2
Molecular Formula:C₂₃H₂₄N₂O₅
Molecular Weight:408.454
Hs Code.:

Synonyms:1-ethyl 2-methyl 3-amino-4-<4-(benzyloxy)benzyl>-1H-pyrrole-1,2-dicarboxylate

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Chemical Property of 1-ethyl 2-methyl 3-amino-4-<4-(benzyloxy)benzyl>-1H-pyrrole-1,2-dicarboxylate

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Technology Process of 1-ethyl 2-methyl 3-amino-4-<4-(benzyloxy)benzyl>-1H-pyrrole-1,2-dicarboxylate

There total 5 articles about 1-ethyl 2-methyl 3-amino-4-<4-(benzyloxy)benzyl>-1H-pyrrole-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 541-41-3
chloroformic acid ethyl ester

: 2-<4-(benzyloxy)benzyl>-3-<(2-methoxy-2-oxoethyl)amino>-2-propenenitrile

: 1027413-96-2
1-ethyl 2-methyl 3-amino-4-<4-(benzyloxy)benzyl>-1H-pyrrole-1,2-dicarboxylate

: 2-<4-(benzyloxy)benzyl>-3-<(ethoxycarbonyl)(2-methoxy-2-oxoethyl)amino>-2-propenenitrile

Guidance literature:: With DBN; In dichloromethane; for 44h;
DOI:10.1021/jm00053a008

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 1027413-96-2
1-ethyl 2-methyl 3-amino-4-<4-(benzyloxy)benzyl>-1H-pyrrole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium acetate, pyridine / pyridine; toluene / 44 h / Heating

2: Mg, MeOH

3: 17 percent / NaH / tetrahydrofuran / 1.) overnight, 2.) reflux, 30 min, 3.) RT, overnight

4: 85 percent / AcONa / methanol; H₂O / 48 h / Ambient temperature

5: 76 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 44 h

With pyridine; ammonium acetate; methanol; DBN; sodium acetate; sodium hydride; magnesium; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; toluene;
DOI:10.1021/jm00053a008

Reference yield:

: 705940-13-2
3-(4-benzyloxyphenyl)acrylonitrile

: 1027413-96-2
1-ethyl 2-methyl 3-amino-4-<4-(benzyloxy)benzyl>-1H-pyrrole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: Mg, MeOH

2: 17 percent / NaH / tetrahydrofuran / 1.) overnight, 2.) reflux, 30 min, 3.) RT, overnight

3: 85 percent / AcONa / methanol; H₂O / 48 h / Ambient temperature

4: 76 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 44 h

With methanol; DBN; sodium acetate; sodium hydride; magnesium; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00053a008