(R)-1-[4-(benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]-phenyl]-2-bromoethanol

Base Information

Chemical Name:(R)-1-[4-(benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]-phenyl]-2-bromoethanol
CAS No.:1313485-98-1
Molecular Formula:C₂₂H₃₁BrO₃Si
Molecular Weight:451.476
Hs Code.:

Synonyms:(R)-1-[4-(benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]-phenyl]-2-bromoethanol

Suppliers and Price of (R)-1-[4-(benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]-phenyl]-2-bromoethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-[4-(benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]-phenyl]-2-bromoethanol

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Technology Process of (R)-1-[4-(benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]-phenyl]-2-bromoethanol

There total 1 articles about (R)-1-[4-(benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]-phenyl]-2-bromoethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 324556-92-5
(R)-(+)-2-bromo-1-(3'-hydroxymethyl-4'-benzyloxyphenyl) ethanol

: 1313485-98-1
(R)-1-[4-(benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]-phenyl]-2-bromoethanol

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 65.0%

: 1313485-98-1
(R)-1-[4-(benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]-phenyl]-2-bromoethanol

: 1313485-89-0
(R)-4-(2-amino-1-hydroxyethyl)-2-[[(tert-butyldimethylsilyl)oxy]methyl]phenol

Guidance literature:: (R)-1-[4-(benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]-phenyl]-2-bromoethanol; With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

With hydrogen; 20 % Pd(OH)2/C; In methanol;

Reference yield:

: 1313485-98-1
(R)-1-[4-(benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]-phenyl]-2-bromoethanol

: 1313485-92-5
(R)-tert-butyl [9-[4-[[(1,1'-biphenyl)-2-ylcarbamoyl]oxy]piperidin-1-yl]nonyl][2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 °C

2.1: acetic acid / dichloromethane / 0.5 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: potassium carbonate / 1,4-dioxane; water / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

With sodium azide; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;