2-(4-chloro-phenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl-carbamic acid tert-butyl ester

Base Information

• Chemical Name: 2-(4-chloro-phenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl-carbamic acid tert-butyl ester
• CAS No.: 1056901-64-4
• Molecular Formula: C₂₂H₂₄ClN₃O₃
• Molecular Weight: 413.904
• Mol file: 1056901-64-4.mol

Synonyms:2-(4-chloro-phenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl-carbamic acid tert-butyl ester

Chemical Property of 2-(4-chloro-phenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chloro-phenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl-carbamic acid tert-butyl ester

There total 4 articles about 2-(4-chloro-phenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

pyrazole-4-boronic acid pinacol ester (269410-08-4) + [2-(4-chloro-phenyl)-2-hydroxy-2-(4-iodo-phenyl)ethyl]-carbamic acid tert-butyl ester (1056901-63-3) → 2-(4-chloro-phenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl-carbamic acid tert-butyl ester (1056901-64-4)

Guidance literature:

pyrazole-4-boronic acid pinacol ester; [2-(4-chloro-phenyl)-2-hydroxy-2-(4-iodo-phenyl)ethyl]-carbamic acid tert-butyl ester; With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; toluene; at 85 ℃; for 25.5h;

With sodium hydroxide; In water;

Reference yield:

(RS)-2-(4-chloro-phenyl)-2-(4-iodo-phenyl)-oxirane (857532-00-4) → 2-(4-chloro-phenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl-carbamic acid tert-butyl ester (1056901-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonia / methanol / 1 h / 130 °C / Microwave irradiation

2: sodium hydroxide / 1,4-dioxane; water / 24 h / 45 °C

3: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; ethanol; water; toluene / 25.5 h / 85 °C

With sodium hydroxide; potassium phosphate; ammonia; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; ethanol; water; toluene;

Reference yield:

2-amino-1-(4-chloro-phenyl)-1-(4-iodo-phenyl)-ethanol (917899-14-0) → 2-(4-chloro-phenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl-carbamic acid tert-butyl ester (1056901-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane; water / 24 h / 45 °C

2: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; ethanol; water; toluene / 25.5 h / 85 °C

With sodium hydroxide; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; ethanol; water; toluene;

upstream raw materials:

pyrazole-4-boronic acid pinacol ester

[2-(4-chloro-phenyl)-2-hydroxy-2-(4-iodo-phenyl)ethyl]-carbamic acid tert-butyl ester

(RS)-2-(4-chloro-phenyl)-2-(4-iodo-phenyl)-oxirane

2-amino-1-(4-chloro-phenyl)-1-(4-iodo-phenyl)-ethanol

Downstream raw materials:

2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol

Refernces