1-methylethyl 4-({7-[2-fluoro-4-(methylthio)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

Base Information

Chemical Name:1-methylethyl 4-({7-[2-fluoro-4-(methylthio)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate
CAS No.:1001399-38-7
Molecular Formula:C₂₂H₂₇FN₄O₃S
Molecular Weight:446.546
Hs Code.:

Synonyms:1-methylethyl 4-({7-[2-fluoro-4-(methylthio)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

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Chemical Property of 1-methylethyl 4-({7-[2-fluoro-4-(methylthio)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

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Technology Process of 1-methylethyl 4-({7-[2-fluoro-4-(methylthio)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

There total 8 articles about 1-methylethyl 4-({7-[2-fluoro-4-(methylthio)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1001399-38-7
1-methylethyl 4-({7-[2-fluoro-4-(methylthio)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

Guidance literature:

Reference yield:

: 832715-51-2
isopropyl 4-hydroxypiperidine-1-carboxylate

: C₁₃H₁₁ClFN₃S

: 1001399-38-7
1-methylethyl 4-({7-[2-fluoro-4-(methylthio)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

Guidance literature:: isopropyl 4-hydroxypiperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; for 0.5h; Reflux;

C₁₃H₁₁ClFN₃S; In tetrahydrofuran; mineral oil; at 20 ℃; for 1.5h; Reflux;
DOI:10.1021/jm301404a

Reference yield:

: 76180-33-1
[2-fluoro-4-(methylthio)phenyl]amine

: 1001399-38-7
1-methylethyl 4-({7-[2-fluoro-4-(methylthio)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid; sodium tris(acetoxy)borohydride / methanol / 19 h / -15 - 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 22 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / Reflux

3.2: 1.5 h / 20 °C / Reflux

With potassium tert-butylate; sodium tris(acetoxy)borohydride; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/jm301404a