76180-33-1

Basic information

• Product Name: 2-fluoro-4-(Methylthio)benzenaMine
• Synonyms: 2-fluoro-4-(Methylthio)benzenaMine;2-Fluoro-4-(methylthio)aniline;4-Amino-3-fluorothioanisole, 2-Fluoro-4-(methylsulphanyl)aniline, 2-Fluoro-4-(methylmercapto)aniline;2-Fluoro-4-(methylsulphanyl)aniline;4-Amino-3-fluorothioanisole, 2-Fluoro-4-(methylthio)aniline;2-fluoro-4-(methylthio)benzene amine
• CAS NO: 76180-33-1
• Molecular Formula: C₇H₈FNS
• Molecular Weight: 157
• Mol File: 76180-33-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 250.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.22±0.1 g/cm3(Predicted)
• PKA: 2.96±0.10(Predicted)
• CAS DataBase Reference: 2-fluoro-4-(Methylthio)benzenaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-4-(Methylthio)benzenaMine(76180-33-1)
• EPA Substance Registry System: 2-fluoro-4-(Methylthio)benzenaMine(76180-33-1)

Safety Data

• Hazardous Substances Data: 76180-33-1(Hazardous Substances Data)

Usage

General Description

2-fluoro-4-(Methylthio)benzenaMine is a chemical compound with the molecular formula C7H8FS. It is an aromatic amine with a fluorine atom and a methylthio group attached to a benzene ring. 2-fluoro-4-(Methylthio)benzenaMine is used in various pharmaceutical and agrochemical applications, including as an intermediate in the synthesis of pharmaceutical compounds such as anti-inflammatory and anti-cancer drugs. It is also used in the manufacture of herbicides and insecticides. 2-fluoro-4-(Methylthio)benzenaMine is considered to be potentially hazardous if inhaled, ingested, or absorbed through the skin, and proper safety precautions should be taken when handling and using this chemical.

Upstream product

• 624-92-0 Dimethyldisulphide 
• 29632-74-4 2-fluro-4-iodoaniline 
• 15178-48-0 4-amino-3-fluorobenzenethiol 
• 74-88-4 methyl iodide 
• 14512-85-7 4-amino-3-fluorophenyl thiocyanate 
• 67-56-1 methanol 

Downstream Products

• 1193488-55-9 6-fluoro-7-(2-fluoro-4-methylsulfanyl-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid 
• 1101132-60-8 N-acetyl-2-fluoro-4-methylthioaniline 
• 1001399-38-7 1-methylethyl 4-({7-[2-fluoro-4-(methylthio)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate 
• 1310693-13-0 6-chloro-N-(2-fluoro-4-(methylsulfonyl)phenyl)-5-nitropyrimidin-4-amine 
• 1424328-52-8 endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1424328-54-0 C₂₄H₃₁FN₆O₆S 
• 1424328-56-2 endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1424361-09-0 C₂₃H₂₈FN₅O₇S 
• 1416137-45-5 C₂₁H₂₉FN₄O₂S 
• 1416137-39-7 C₂₂H₂₇FN₆O₂S 
• 1416137-37-5 C₂₁H₂₇FN₄O₄S 

Relevant articles and documents

Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available g protein-coupled receptor 119 agonists

GPR119 is a 7-transmembrane receptor that is expressed in the enteroendocrine cells in the intestine and in the islets of Langerhans in the pancreas. Indolines and 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines were discovered as G protein-coupled receptor 119

Heterocyclic Compounds as MEK Inhibitors

The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof.