76180-33-1

Usage

Uses

Used in Pharmaceutical Industry:
2-fluoro-4-(Methylthio)benzenaMine is used as a chemical intermediate for the synthesis of pharmaceutical compounds, specifically targeting the development of anti-inflammatory and anti-cancer drugs. Its unique structural features contribute to the modulation of biological activities, making it a valuable component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-fluoro-4-(Methylthio)benzenaMine is utilized in the production of herbicides and insecticides. Its incorporation into these products enhances their effectiveness in controlling weeds and pests, thereby supporting agricultural productivity and crop protection.
Safety Precautions:
Given its potential hazards when inhaled, ingested, or absorbed through the skin, 2-fluoro-4-(Methylthio)benzenaMine requires stringent safety measures during its handling and application. Adequate personal protective equipment and handling protocols must be adhered to minimize risks associated with this chemical compound.

Upstream product

• 14512-85-7 4-amino-3-fluorophenyl thiocyanate 
• 74-88-4 methyl iodide 
• 624-92-0 Dimethyldisulphide 
• 29632-74-4 2-fluro-4-iodoaniline 
• 67-56-1 methanol 
• 15178-48-0 4-amino-3-fluorobenzenethiol 

Downstream Products

• 1057221-20-1 methyl 2-(2-fluoro-4-(methylthio)phenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 
• 869357-39-1 methyl 4-(2-fluoro-4-(methylthio)phenylamino)-1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate 
• 1163765-10-3 N-(2-fluoro-4-methylsulfanyl-phenyl)-malonamic acid methyl ester 
• 1193488-55-9 6-fluoro-7-(2-fluoro-4-methylsulfanyl-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid 
• 1203662-80-9 4-fluoro-2-(2-fluoro-4-methylsulfanyl-phenylamino)-3-formyl-benzoic acid 
• 1203662-88-7 7-(2-fluoro-4-methylsulfanyl-phenylamino)-benzo[d]isothiazole-6-carboxylic acid 
• 1101132-60-8 N-acetyl-2-fluoro-4-methylthioaniline 
• 1424361-09-0 C₂₃H₂₈FN₅O₇S 
• 1424328-56-2 endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1424328-54-0 C₂₄H₃₁FN₆O₆S 
• 1424328-52-8 endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1310693-13-0 6-chloro-N-(2-fluoro-4-(methylsulfonyl)phenyl)-5-nitropyrimidin-4-amine 

Relevant academic research and scientific papers

Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available g protein-coupled receptor 119 agonists

GPR119 is a 7-transmembrane receptor that is expressed in the enteroendocrine cells in the intestine and in the islets of Langerhans in the pancreas. Indolines and 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines were discovered as G protein-coupled receptor 119

4-(TRICHLOROMETHYLTHIO)ANILINE, METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING 4-(TRIFLUOROMETHYLTHIO)ANILINE

There are provided a 4-(trichloromethylthio)aniline represented by the general formula (II): wherein R1 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R2 each independently represents a halogen atom, an alkyl group having 1 to 3 carbon atoms, or a perfluoroalkyl group having 1 to 3 carbon atoms, R3 represents a formyl group, an acetyl group, or a trifluoroacetyl group, and m represents an integer of 0 to 4, a method for producing the same, and a method for producing a 4-(trifluoromethylthio)aniline derivative using the 4-(trichloromethylthio)aniline. It becomes possible to produce a 4-(trifluoromethylthio)aniline with a high yield by using raw materials that can easily be obtained industrially and using general purpose production facilities.

Heterocyclic Compounds as MEK Inhibitors

The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof.

N-(4-substituted phenyl)-anthranilic acid hydroxamate esters

The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.