8-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

Base Information

Chemical Name:8-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one
CAS No.:77211-59-7
Molecular Formula:C₁₇H₂₄N₂O₅
Molecular Weight:336.388
Hs Code.:
ChEMBL ID:CHEMBL24740
DSSTox Substance ID:DTXSID401139208
Wikidata:Q107963039

Synonyms:8-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one;77211-59-7;8-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one;CHEMBL24740;SCHEMBL11364347;OAYWXPDKMZAXSF-UHFFFAOYSA-N;DTXSID401139208;Z1771679985

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:336.16852187
Heavy Atom Count:24
Complexity:425

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC=C1OCC(CN2CCC3(CC2)CNC(=O)O3)O

Technology Process of 8-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

There total 2 articles about 8-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 5052-95-9
1-oxa-3,8-diazaspiro[4.5]-decan-2-one

: 2210-74-4
2-(2-methoxy-phenoxymethyl)-oxirane

: 77211-59-7
8-[2-Hydroxy-3-(2-methoxy-phenoxy)-propyl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one

Guidance literature:: With triethylamine;
DOI:10.1021/jm00143a012

Reference yield:

: 5053-14-5
8-Benzyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one

: 77211-59-7
8-[2-Hydroxy-3-(2-methoxy-phenoxy)-propyl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / 16 h / 50 °C

2: 68 percent / Et₃N

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00143a012