Trimethylene carbonate

Base Information

Chemical Name:Trimethylene carbonate
CAS No.:2453-03-4
Molecular Formula:C4H6O3
Molecular Weight:102.09
Hs Code.:29147000
European Community (EC) Number:607-395-4
UNII:4316AQ174Q
DSSTox Substance ID:DTXSID20953766
Nikkaji Number:J277.252C
Wikipedia:Trimethylene_carbonate
Wikidata:Q161506
Mol file:2453-03-4.mol

Synonyms:1,3-carbonyldioxypropane;1,3-dioxan-2-one;trimethylene carbonate

Suppliers and Price of Trimethylene carbonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,3-Dioxan-2-one
500mg
$ 155.00

TCI Chemical
1,3-Dioxan-2-one >98.0%(GC)
25g
$ 692.00

TCI Chemical
1,3-Dioxan-2-one >98.0%(GC)
5g
$ 248.00

SynQuest Laboratories
1,3-Dioxan-2-one
5 g
$ 176.00

SynQuest Laboratories
1,3-Dioxan-2-one
1 g
$ 48.00

Matrix Scientific
1,3-Dioxan-2-one
5g
$ 570.00

Biosynth Carbosynth
1,3-Dioxan-2-one
10 g
$ 300.00

Biosynth Carbosynth
1,3-Dioxan-2-one
5 g
$ 180.00

Biosynth Carbosynth
1,3-Dioxan-2-one
25 g
$ 600.00

Biosynth Carbosynth
1,3-Dioxan-2-one
2 g
$ 100.00

Total 62 raw suppliers

Chemical Property of Trimethylene carbonate

Chemical Property:

Vapor Pressure:0.0165mmHg at 25°C
Melting Point:45.0 to 49.0 °C
Refractive Index:1.425
Boiling Point:255.2 °C at 760 mmHg
Flash Point:148.6 °C
PSA：35.53000
Density:1.2 g/cm³
LogP:0.54330
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Solubility.:soluble in Methanol
XLogP3:0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:102.031694049
Heavy Atom Count:7
Complexity:71

Purity/Quality:

99% ^*data from raw suppliers

1,3-Dioxan-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 22-36
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COC(=O)OC1
General Description 1,3-Dioxan-2-one (trimethylene carbonate) is a cyclic carbonate monomer used in ring-opening polymerizations to synthesize biodegradable polycarbonates, such as poly(trimethylene carbonate) (PTMC). It serves as a key precursor in mechanochemical polymerizations, where solvent-free, high-conversion reactions are achieved with organocatalysts like DBU and TBD, demonstrating significant rate acceleration under ball-milling conditions. Additionally, it is employed in the synthesis of polyester- and poly(ester-carbonate)-drug conjugates, such as paclitaxel derivatives, contributing to controlled drug delivery systems. Its reactivity and versatility make it valuable in green chemistry applications, including CO₂ conversion into cyclic carbonates when catalyzed by supported POSS-based materials.

Technology Process of Trimethylene carbonate

There total 33 articles about Trimethylene carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 503-30-0
trimethylene oxide

: 124-38-9,18923-20-1
carbon dioxide

: 2453-03-4,31852-84-3
trimethylene carbonate

Guidance literature:: With bis(acetylacetonate)oxovanadium; tetrabutylammomium bromide; In toluene; at 60 ℃; for 8h; under 26252.6 Torr; chemoselective reaction; Autoclave; Cooling with ice;
DOI:10.1039/c0gc00136h

Reference yield: 99.0%

: 332-25-2
4-(trifluoromethoxy)benzonitrile

: 504-63-2
trimethyleneglycol

: 2453-03-4,31852-84-3
trimethylene carbonate

Guidance literature:: With 3,7-di([1,1′-biphenyl]-4-yl)-10-(naphthalen-1-yl)-10H-phenoxazine; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 24h; Reagent/catalyst; Inert atmosphere; Irradiation; Sealed tube;
DOI:10.1002/chem.201804603

Reference yield: 95.0%

: 124-38-9,18923-20-1
carbon dioxide

: 627-30-5
1-chloro-3-hydroxypropane

: 2453-03-4,31852-84-3
trimethylene carbonate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 15h; under 760.051 Torr; Reagent/catalyst; Temperature; Inert atmosphere; Glovebox; Green chemistry;
DOI:10.1039/c3gc40790j