N-(3-Hydroxypropyl)aniline

Base Information

• Chemical Name: N-(3-Hydroxypropyl)aniline
• CAS No.: 31121-11-6
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• Hs Code.: 2922199090
• Mol file: 31121-11-6.mol

Synonyms:N-phenylamino-3 propanol-1;3-Anilino-1-propanol;N-(3-Hydroxypropyl)aniline;3-hydroxy-N-phenylpropylamine;

Chemical Property of N-(3-Hydroxypropyl)aniline

Chemical Property:

• Vapor Pressure: 0.000195mmHg at 25°C
• Refractive Index: 1.5710-1.5750
• Boiling Point: 314.6oC at 760 mmHg
• PKA: 14.88±0.10(Predicted)
• Flash Point: 156.7oC
• PSA: 32.26000
• Density: 1.084g/cm3
• LogP: 1.55390
• Storage Temp.: 0-10°C

Purity/Quality:

98% ^*data from raw suppliers

3-Anilino-1-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-Hydroxypropyl)aniline

There total 41 articles about N-(3-Hydroxypropyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(1,2-dioxolan-3-yl)-N-phenylamine (400777-76-6) → 3-hydroxy-N-phenylpropylamine (31121-11-6)

Guidance literature:

With hydrogen; 10percent Pd/C; In methanol;

DOI:10.1002/1099-0690(200110)2001:20<3811::AID-EJOC3811>3.0.CO;2-6

Reference yield: 97.0%

iodobenzene (591-50-4) + propan-1-ol-3-amine (156-87-6) → 3-hydroxy-N-phenylpropylamine (31121-11-6)

Guidance literature:

With copper(l) chloride; potassium hydroxide; at 20 ℃; for 8h; Neat (no solvent);

DOI:10.1016/j.tetlet.2011.12.130

Reference yield: 93.0%

trimethylene oxide (503-30-0) + aniline (62-53-3) → 3-hydroxy-N-phenylpropylamine (31121-11-6)

Guidance literature:

With lithium tetrafluoroborate; In acetonitrile; for 64h; Ambient temperature;

DOI:10.1016/S0040-4039(00)75811-4

upstream raw materials:

3-bromopropyl benzoate

aniline

1-chloro-3-hydroxypropane

3-phenyl-1,3-oxazinan-2-one

Downstream raw materials:

3-((hydroxyethyl)(phenyl)amino)propan-1-ol

julolidine

aniline

2,3,6,7-tetrahydro-9-methoxy-1H,5H-benzo[ij]quinolizine

Refernces

• 1、 Das, Kuhali,Sarkar, Koushik,Maji, Biplab. "Manganese-Catalyzed Anti-Markovnikov Hydroamination of Allyl Alcohols via Hydrogen-Borrowing Catalysis". . p. 7060 - 7069. Retrieved 2021/06/30.
• 2、 Ma, Wei,Zhang, Xiaohui,Fan, Juan,Liu, Yuxuan,Tang, Weijun,Xue, Dong,Li, Chaoqun,Xiao, Jianliang,Wang, Chao. "Iron-Catalyzed Anti-Markovnikov Hydroamination and Hydroamidation of Allylic Alcohols". supporting information. p. 13506 - 13515. Retrieved 2019/09/09.