4-(t-butyldimethylsilanyloxy)-3-methyl-7-phenyl-3H-furo[3,2-c]pyridin-2-one

Base Information

Chemical Name:4-(t-butyldimethylsilanyloxy)-3-methyl-7-phenyl-3H-furo[3,2-c]pyridin-2-one
CAS No.:756499-61-3
Molecular Formula:C₂₀H₂₅NO₃Si
Molecular Weight:355.509
Hs Code.:

Synonyms:4-(t-butyldimethylsilanyloxy)-3-methyl-7-phenyl-3H-furo[3,2-c]pyridin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(t-butyldimethylsilanyloxy)-3-methyl-7-phenyl-3H-furo[3,2-c]pyridin-2-one

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Technology Process of 4-(t-butyldimethylsilanyloxy)-3-methyl-7-phenyl-3H-furo[3,2-c]pyridin-2-one

There total 7 articles about 4-(t-butyldimethylsilanyloxy)-3-methyl-7-phenyl-3H-furo[3,2-c]pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 756499-59-9
2,4-bis(t-butyldimethylsilanyloxy)-3-methyl-7-phenylfuro[3,2-c]pyridine

: 756499-61-3
4-(t-butyldimethylsilanyloxy)-3-methyl-7-phenyl-3H-furo[3,2-c]pyridin-2-one

Guidance literature:: With triethylamine; In dichloromethane; water; at 25 ℃; for 0.333333h;
DOI:10.1021/ol049130t

Reference yield:

: 756499-57-7
ethyl 3-(4-chlorophenylsulfanyl)-2-(4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridine-3-yl)propionate

: 756499-61-3
4-(t-butyldimethylsilanyloxy)-3-methyl-7-phenyl-3H-furo[3,2-c]pyridin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Raney nickel / acetone; ethanol; H₂O / 12 h / 25 °C

2: 93 percent / TFA / toluene / 12 h / 110 °C

3: Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: 324 mg / Et₃N / CH₂Cl₂; H₂O / 0.33 h / 25 °C

With triethylamine; trifluoroacetic acid; nickel; In ethanol; dichloromethane; water; acetone; toluene;
DOI:10.1021/ol049130t

Reference yield:

: 102249-52-5
4-hydroxy-5-phenylpyridin-2(1H)-one

: 756499-61-3
4-(t-butyldimethylsilanyloxy)-3-methyl-7-phenyl-3H-furo[3,2-c]pyridin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 40 percent / HCOOH; Et₃N / 5 h / 140 - 150 °C / sealed tube

2: 98 percent / conc. H₂SO₄ / ethanol / 60 °C

3: 93 percent / TFA / toluene / 12 h / 110 °C

4: Et₃N / CH₂Cl₂ / 1 h / 0 °C

5: 324 mg / Et₃N / CH₂Cl₂; H₂O / 0.33 h / 25 °C

With formic acid; sulfuric acid; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; toluene; 1: Knoevenagel condensation;
DOI:10.1021/ol049130t