bis(4-methoxybenzyl) rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

Base Information

Chemical Name:bis(4-methoxybenzyl) rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate
CAS No.:1312438-51-9
Molecular Formula:C₄₃H₄₅O₁₂PS
Molecular Weight:816.863
Hs Code.:

Synonyms:bis(4-methoxybenzyl) rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

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Chemical Property of bis(4-methoxybenzyl) rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

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Technology Process of bis(4-methoxybenzyl) rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

There total 4 articles about bis(4-methoxybenzyl) rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1312438-75-7
bis(4-methoxybenzyl) rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}-4-pentanedioate

: 4124-41-8
p-toluenesulfonylanhydride

: 1312438-51-9
bis(4-methoxybenzyl) rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

Guidance literature:: bis(4-methoxybenzyl) rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}-4-pentanedioate; With pyridine; hydrogen fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 4.5h;

With boric acid; potassium hydroxide; In tetrahydrofuran; water; pH=7; Cooling with ice;

p-toluenesulfonylanhydride; With pyridine; at 0 - 20 ℃;

Reference yield:

: 1312438-70-2
dimethyl 2-hydroxy-4-methylenepentanedioate

: 1312438-51-9
bis(4-methoxybenzyl) rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-methyl-1H-imidazole / dichloromethane / 0 - 20 °C

2.1: oxo[hexa(trifluoroacetato)]tetrazinc / di-isopropyl ether / 80 °C / Molecular sieve

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C

4.1: pyridine; hydrogen fluoride / tetrahydrofuran / 4.5 h / 0 - 20 °C

4.2: pH 7 / Cooling with ice

4.3: 0 - 20 °C

With pyridine; 1-methyl-1H-imidazole; hydrogen fluoride; potassium carbonate; oxo[hexa(trifluoroacetato)]tetrazinc; In tetrahydrofuran; dichloromethane; di-isopropyl ether; N,N-dimethyl-formamide;

Reference yield:

: 1312438-71-3
dimethyl (RS)-2-{[tert-butyl(dimethyl)silyl]oxy}-4-methylenepentanedioate

: 1312438-51-9
bis(4-methoxybenzyl) rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxo[hexa(trifluoroacetato)]tetrazinc / di-isopropyl ether / 80 °C / Molecular sieve

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C

3.1: pyridine; hydrogen fluoride / tetrahydrofuran / 4.5 h / 0 - 20 °C

3.2: pH 7 / Cooling with ice

3.3: 0 - 20 °C

With pyridine; hydrogen fluoride; potassium carbonate; oxo[hexa(trifluoroacetato)]tetrazinc; In tetrahydrofuran; di-isopropyl ether; N,N-dimethyl-formamide;