tert-Butyl-((1R,3aR,4R,7aS)-7a-{3-[1-ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-yloxy)-dimethyl-silane

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Chemical Name:tert-Butyl-((1R,3aR,4R,7aS)-7a-{3-[1-ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-yloxy)-dimethyl-silane
CAS No.:197647-31-7
Molecular Formula:C₃₆H₆₂O₄Si
Molecular Weight:586.971
Hs Code.:

tert-Butyl-((1R,3aR,4R,7aS)-7a-{3-[1-ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-yloxy)-dimethyl-silane

Synonyms:tert-Butyl-((1R,3aR,4R,7aS)-7a-{3-[1-ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-yloxy)-dimethyl-silane

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Chemical Property of tert-Butyl-((1R,3aR,4R,7aS)-7a-{3-[1-ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-yloxy)-dimethyl-silane

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Technology Process of tert-Butyl-((1R,3aR,4R,7aS)-7a-{3-[1-ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-yloxy)-dimethyl-silane

There total 6 articles about tert-Butyl-((1R,3aR,4R,7aS)-7a-{3-[1-ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-yloxy)-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2-[1-(3-bromomethyl-phenyl)-1-ethyl-propoxy]-tetrahydro-pyran

: 197647-68-0
8R-tert-butyldimethylsilyloxy-20-methyl-de-A,B-pregnan-18-ol

: 197647-31-7
tert-Butyl-((1R,3aR,4R,7aS)-7a-{3-[1-ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-yloxy)-dimethyl-silane

Guidance literature:: With 18-crown-6 ether; potassium hydride; In tetrahydrofuran; for 0.333333h; Ambient temperature;
DOI:10.1016/S0968-0896(98)00161-8

Reference yield:

: 66774-80-9,111924-49-3
(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

: 197647-31-7
tert-Butyl-((1R,3aR,4R,7aS)-7a-{3-[1-ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-yloxy)-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 21 h / Heating

2: 88 percent / lead tetraacetate, pyridine / benzene / 3.5 h / 15 °C / Irradiation

3: 39 percent / boron trifluoride etherate / -20 deg C, 45 min, room temperature, 1 h

4: 65 percent / potassium hydroxide / methanol / 2.5 h / Heating

5: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

6: 80 percent / potassium hydride, 18-crown-6 / tetrahydrofuran / 0.33 h / Ambient temperature

With pyridine; 1H-imidazole; lead(IV) acetate; potassium hydroxide; lithium aluminium tetrahydride; 18-crown-6 ether; boron trifluoride diethyl etherate; potassium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(98)00161-8

Reference yield:

: 197647-61-3
20-methyl-de-A,B-pregnan-(8S)-ol

: 197647-31-7
tert-Butyl-((1R,3aR,4R,7aS)-7a-{3-[1-ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-yloxy)-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / lead tetraacetate, pyridine / benzene / 3.5 h / 15 °C / Irradiation

2: 39 percent / boron trifluoride etherate / -20 deg C, 45 min, room temperature, 1 h

3: 65 percent / potassium hydroxide / methanol / 2.5 h / Heating

4: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

5: 80 percent / potassium hydride, 18-crown-6 / tetrahydrofuran / 0.33 h / Ambient temperature

With pyridine; 1H-imidazole; lead(IV) acetate; potassium hydroxide; 18-crown-6 ether; boron trifluoride diethyl etherate; potassium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(98)00161-8