N-{2-chloro-5-[(cyclopropylamino)carbonyl]phenyl}-1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide

Base Information

Chemical Name:N-{2-chloro-5-[(cyclopropylamino)carbonyl]phenyl}-1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide
CAS No.:1082293-89-7
Molecular Formula:C₂₂H₁₆Cl₃N₃O₃
Molecular Weight:476.746
Hs Code.:

Synonyms:N-{2-chloro-5-[(cyclopropylamino)carbonyl]phenyl}-1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide

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Chemical Property of N-{2-chloro-5-[(cyclopropylamino)carbonyl]phenyl}-1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide

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Technology Process of N-{2-chloro-5-[(cyclopropylamino)carbonyl]phenyl}-1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide

There total 5 articles about N-{2-chloro-5-[(cyclopropylamino)carbonyl]phenyl}-1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1082295-91-7
4-chloro-3-({[1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinyl]carbonyl}amino)benzoic acid

: 765-30-0
Cyclopropylamine

: 1082293-89-7
N-{2-chloro-5-[(cyclopropylamino)carbonyl]phenyl}-1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; at 0 - 20 ℃; for 16h;

Reference yield:

: 114106-77-3
methyl 4-carbomethoxy-5-methoxy-penta-2(E),4(Z)-dienoate

: 1082293-89-7
N-{2-chloro-5-[(cyclopropylamino)carbonyl]phenyl}-1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

1.2: 3 h / 0 °C

2.1: sodium methylate / methanol / 8 h / Heating / reflux

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -10 - -5 °C

3.2: 3 h / -10 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / 16 h / 0 - 20 °C

With sodium methylate; N-ethyl-N,N-diisopropylamine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;

Reference yield:

: 1082295-38-2
dimethyl (2E,4Z)-4-{[(2,6-dichlorophenyl)amino]methylene}-2-pentenedioate

: 1082293-89-7
N-{2-chloro-5-[(cyclopropylamino)carbonyl]phenyl}-1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 8 h / Heating / reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -10 - -5 °C

2.2: 3 h / -10 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / 16 h / 0 - 20 °C

With sodium methylate; N-ethyl-N,N-diisopropylamine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;