ethyl 5-[2-fluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

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Chemical Name:ethyl 5-[2-fluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate
CAS No.:1429511-03-4
Molecular Formula:C₂₄H₂₆FN₃O₄
Molecular Weight:439.487
Hs Code.:

Synonyms:ethyl 5-[2-fluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 5-[2-fluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 5-[2-fluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

There total 7 articles about ethyl 5-[2-fluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429510-62-2
2-fluoro-4-iodo-3,5-dimethylpyridine

: 1429511-03-4
ethyl 5-[2-fluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; methanol / 2 h / 55 - 65 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 6 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 2369-19-9
2-fluoro-5-methylpyridine

: 1429511-03-4
ethyl 5-[2-fluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 3.5 h / -75 °C

1.2: 1.92 h / -75 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1.5 h / -74 - -72 °C

2.2: 2 h / -74 - -70 °C

3.1: tetrahydrofuran; methanol / 2 h / 55 - 65 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 6 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water;

Reference yield:

: 112704-80-0
ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate

: 1429511-03-4
ethyl 5-[2-fluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2.25 h / 50 °C

1.2: 2.75 h / 50 °C

2.1: potassium acetate; Pd(dppf)₂·CH₂Cl₂ / N,N-dimethyl-formamide / 3.17 h / 80 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 6 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd(dppf)₂·CH₂Cl₂; potassium acetate; caesium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;