4-(3-Bromopropyl)morpholine

Base Information

• Chemical Name: 4-(3-Bromopropyl)morpholine
• CAS No.: 125422-83-5
• Molecular Formula: C7H14BrNO
• Molecular Weight: 208.098
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20515924
• Wikidata: Q72493013
• Mol file: 125422-83-5.mol

Synonyms:4-(3-bromopropyl)morpholine;125422-83-5;3-morpholinopropyl bromide;Morpholine, 4-(3-bromopropyl)-;3-Morpholinopropylbromide;SCHEMBL1054743;DTXSID20515924;AFUWTOMPIDVMSJ-UHFFFAOYSA-N;AKOS010540770;AM86452;PB40084;BS-13301;CS-0055734;N10280;A805382;J-512946

Chemical Property of 4-(3-Bromopropyl)morpholine

Chemical Property:

• Appearance/Colour: White or off-white crystal powder
• Vapor Pressure: 0.0337mmHg at 25°C
• Refractive Index: 1.493
• Boiling Point: 242.6 °C at 760 mmHg
• PKA: 6.94±0.10(Predicted)
• Flash Point: 100.5 °C
• PSA: 12.47000
• Density: 1.335 g/cm³
• LogP: 1.04150
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 207.02588
• Heavy Atom Count: 10
• Complexity: 83.7

Purity/Quality:

≥99% ^*data from raw suppliers

4-(3-Bromopropyl)morpholine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CCCBr

Technology Process of 4-(3-Bromopropyl)morpholine

There total 4 articles about 4-(3-Bromopropyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-morpholin-4-ylpropan-1-ol (4441-30-9) → 4 (3-bromopropyl)-morpholine (125422-83-5)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2009.05.102

Reference yield: 80.0%

morpholine (110-91-8,99108-56-2) + 1.3-chlorobromopropane (109-70-6) → 4 (3-bromopropyl)-morpholine (125422-83-5)

Guidance literature:

In toluene; at 70 ℃; for 3h;

Reference yield: 50.0%

→ 4 (3-bromopropyl)-morpholine (125422-83-5)

Guidance literature:

With carbon tetrabromide; In dichloromethane; at -18 ℃; for 0.25h;

With triphenylphosphine; In dichloromethane; for 1h;

upstream raw materials:

3-morpholin-4-ylpropan-1-ol

morpholine

1.3-chlorobromopropane

1,3-dibromo-propane

Downstream raw materials:

2-adamantan-1-yl-N-[3-(3-morpholin-4-yl-propoxy)cyclohexyl]acetamide

C₁₈H₁₈F₃N₅O₃

(3-chloro-4-fluorophenyl)-[7-(3-morpholino-4-yl-propoxy)-6-nitroquinazolin-4-yl]-amine

4-(3-(4-iodophenoxy)propyl)morpholine