4-chloro-2'-(4-methyl-1-piperidinyl)-5'-<(benzyloxycarbonyl)amino>benzophenone

Base Information

Chemical Name:4-chloro-2'-(4-methyl-1-piperidinyl)-5'-<(benzyloxycarbonyl)amino>benzophenone
CAS No.:86187-91-9
Molecular Formula:C₂₇H₂₇ClN₂O₃
Molecular Weight:462.976
Hs Code.:

Synonyms:4-chloro-2'-(4-methyl-1-piperidinyl)-5'-<(benzyloxycarbonyl)amino>benzophenone

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Chemical Property of 4-chloro-2'-(4-methyl-1-piperidinyl)-5'-<(benzyloxycarbonyl)amino>benzophenone

Chemical Property:

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Technology Process of 4-chloro-2'-(4-methyl-1-piperidinyl)-5'-<(benzyloxycarbonyl)amino>benzophenone

There total 4 articles about 4-chloro-2'-(4-methyl-1-piperidinyl)-5'-<(benzyloxycarbonyl)amino>benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 86187-86-2
[2-(4-methyl-1-piperidinyl)-5-aminophenyl]-(4-chlorophenyl)-methanone

: 501-53-1,94274-21-2
benzyl chloroformate

: 86187-91-9
4-chloro-2'-(4-methyl-1-piperidinyl)-5'-<(benzyloxycarbonyl)amino>benzophenone

Guidance literature:: With potassium carbonate; In toluene; for 2h; Ambient temperature;
DOI:10.1021/jm00109a004

Reference yield:

: 2516-96-3
2-chloro-5-nitrobenzoic acid

: 86187-91-9
4-chloro-2'-(4-methyl-1-piperidinyl)-5'-<(benzyloxycarbonyl)amino>benzophenone

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / PCl₅ / chlorobenzene / 1.) RT, 24 h, 2.) 50 deg C, 1 h

2: 83 percent / AlCl₃ / 24 h / Ambient temperature

3: 86 percent / K₂CO₃ / ethanol / 2 h / Heating

4: 65 percent / Fe, 1 N HCl / ethanol / 15 h / Heating

5: 71 percent / K₂CO₃ / toluene / 2 h / Ambient temperature

With hydrogenchloride; aluminium trichloride; phosphorus pentachloride; iron; potassium carbonate; In ethanol; chlorobenzene; toluene;
DOI:10.1021/jm00109a004

Reference yield:

: 25784-91-2
2-chloro-5-nitrobenzoylchloride

: 86187-91-9
4-chloro-2'-(4-methyl-1-piperidinyl)-5'-<(benzyloxycarbonyl)amino>benzophenone

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / AlCl₃ / 24 h / Ambient temperature

2: 86 percent / K₂CO₃ / ethanol / 2 h / Heating

3: 65 percent / Fe, 1 N HCl / ethanol / 15 h / Heating

4: 71 percent / K₂CO₃ / toluene / 2 h / Ambient temperature

With hydrogenchloride; aluminium trichloride; iron; potassium carbonate; In ethanol; toluene;
DOI:10.1021/jm00109a004