86187-86-2

Basic information

• Product Name: 1-[2-(4-Methylpiperidin-1-yl)-5-aminophenyl]-1-(4-chlorophenyl)methanone
• Synonyms: LF-1695; 2-(4-Methylpiperidin-1-yl)-5-amino-4'-chlorobenzophenone; [5-amino-2-(4-methylpiperidin-1-yl)phenyl](4-chlorophenyl)methanone
• CAS NO: 86187-86-2
• Molecular Formula: C₁₉H₂₁ClN₂O
• Molecular Weight: 328.8358
• Mol File: 86187-86-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 529.2°C at 760 mmHg
• Flash Point: 273.8°C
• Density: 1.199g/cm³
• Vapor Pressure: 2.77E-11mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 1-[2-(4-Methylpiperidin-1-yl)-5-aminophenyl]-1-(4-chlorophenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(4-Methylpiperidin-1-yl)-5-aminophenyl]-1-(4-chlorophenyl)methanone(86187-86-2)
• EPA Substance Registry System: 1-[2-(4-Methylpiperidin-1-yl)-5-aminophenyl]-1-(4-chlorophenyl)methanone(86187-86-2)

Safety Data

• Hazardous Substances Data: 86187-86-2(Hazardous Substances Data)

Usage

Molecular structure

The compound has a complex molecular structure consisting of a piperidine ring, an aminophenyl group, a methanone group, and a chlorophenyl group.

Amine and ketone functionalities

The compound exhibits both amine and ketone functionalities, which can be important for pharmacological activity.

Interaction with neurotransmitter receptors

The presence of the piperidine ring suggests that the compound may interact with neurotransmitter receptors in the central nervous system.

Potential drug candidate

Due to its structural features, the compound is a potential drug candidate.

Molecular weight

The molecular weight of the compound is approximately 394.93 g/mol.

Appearance

The compound is likely to be a solid, based on its molecular weight and structure.

Solubility

The compound's solubility is not explicitly mentioned, but it may be soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO) due to its nonpolar nature.

Stability

The stability of the compound is not explicitly mentioned, but it may be sensitive to light, heat, or moisture, as many pharmaceutical compounds are. Proper storage conditions should be maintained to preserve its integrity.

Upstream product

• 70132-91-1 2-chloro-5-nitro-4'-chlorobenzophenone 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 
• 86187-85-1 [2-(4-methyl-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)-methanone 

Downstream Products

• 86187-89-5 (4-Chloro-phenyl)-[5-methylamino-2-(4-methyl-piperidin-1-yl)-phenyl]-methanone 
• 86187-91-9 4-chloro-2'-(4-methyl-1-piperidinyl)-5'-<(benzyloxycarbonyl)amino>benzophenone 
• 86187-90-8 4,5'-dichloro-2'-(4-methyl-1-piperidinyl)benzophenone 
• 86188-01-4 4-chloro-2'-(4-methyl-1-piperidinyl)benzophenone 
• 86187-87-3 [3-(4-Chloro-benzoyl)-4-(4-methyl-piperidin-1-yl)-phenyl]-carbamic acid ethyl ester 
• 86187-93-1 4-chloro-5'-(dimethylamino)-2'-(4-methyl-1-piperidinyl)benzophenone 

Relevant articles and documents

(Benzoylphenyl)piperidines: A new class of immunomodulators

A series of (benzoylphenyl)piperidines has been synthesized and evaluated for activity as immunomodulators. Several of these compounds show good activity in primary screening on the basis of the lymphocytes mitogenic response to Con A, PHA, and PWM. A chloro group in position 4 of the benzoyl moiety as well as an amino group (or a carbamate derivative) para to the piperidine nucleus seems to be essential for activity. The depicted compounds may be considered as the first examples of a new series of immunomodulators.