4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester

Base Information

• Chemical Name: 4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester
• CAS No.: 459819-54-6
• Molecular Formula: C₁₇H₂₂F₃NO₃
• Molecular Weight: 345.362
• Mol file: 459819-54-6.mol

Synonyms:4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester

Chemical Property of 4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester

There total 11 articles about 4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(4-(trifluoromethoxy)phenyl)-5,6-dihydropyridin-1(2H)-carboxylate tert-butyl ester (462127-22-6) → 4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester (459819-54-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.5b00176

Reference yield: 90.0%

(4-(trifluoromethoxy)-phenyl)magnesium bromide (169222-42-8) + tert-butyl 4-iodopiperidine-1-carboxylate (301673-14-3) → 4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester (459819-54-6)

Guidance literature:

With Li₂CoCl₄; In tetrahydrofuran; at 0 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201710931

Reference yield: 56.0%

1-bromo-4-(trifluoromethoxy)benzene (407-14-7) + 2-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)-2-oxoacetic acid → 4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester (459819-54-6)

Guidance literature:

With TETRAHYDROPYRANE; cesium bicarbonate; [Ir(dF(H)ppy)₂(dtbbpy)](PF₆); 4,4'-di-tert-butyl-2,2'-bipyridine nickel(II) bromide; In dimethyl sulfoxide; at 70 ℃; for 4h; Inert atmosphere; Irradiation;

DOI:10.1021/jacs.6b09533

upstream raw materials:

1-bromo-4-(trifluoromethoxy)benzene

N-tert-butyloxycarbonylpiperidin-4-one

4-hydroxy-4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester

4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide