(4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methanamine

Base Information

• Chemical Name: (4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methanamine
• CAS No.: 1426520-69-5
• Molecular Formula: C₁₉H₂₁F₃N₂O
• Molecular Weight: 350.384
• Mol file: 1426520-69-5.mol

Synonyms:(4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methanamine

Chemical Property of (4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methanamine

Chemical Property:

Purity/Quality:

95-99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methanamine

There total 13 articles about (4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzonitrile (1613627-57-8) → (4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methanamine (1426520-69-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 6.5h; Reflux;

DOI:10.1021/acsmedchemlett.5b00176

Reference yield:

4-(4-(trifluoromethoxy)phenyl)piperidine (180160-91-2) → (4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methanamine (1426520-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 90 - 120 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Reflux; Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1021/jm5003606

Reference yield:

4-fluorobenzonitrile (1194-02-1,143234-87-1) → (4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methanamine (1426520-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 90 - 120 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Reflux; Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1021/jm5003606

upstream raw materials:

4-fluorobenzonitrile

4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzonitrile

4-(4-(trifluoromethoxy)phenyl)piperidine

4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester