4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzonitrile

Base Information

• Chemical Name: 4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzonitrile
• CAS No.: 1613627-57-8
• Molecular Formula: C₁₉H₁₇F₃N₂O
• Molecular Weight: 346.352
• Mol file: 1613627-57-8.mol

Synonyms:4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzonitrile

Chemical Property of 4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzonitrile

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzonitrile

There total 14 articles about 4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4-cyanophenyl)zinc pivalate + 4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl benzoate → 4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzonitrile (1613627-57-8)

Guidance literature:

With Li₂CoCl₄; In tetrahydrofuran; at 25 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201710931

Reference yield: 74.6%

4-Cyanochlorobenzene (623-03-0) + 4-(4-(trifluoromethoxy)phenyl)piperidine (180160-91-2) → 4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzonitrile (1613627-57-8)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 150 ℃;

DOI:10.1021/acsmedchemlett.5b00176

Reference yield: 73.0%

4-(4-(trifluoromethoxy)phenyl)piperidine (180160-91-2) + 4-bromobenzenecarbonitrile (623-00-7) → 4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzonitrile (1613627-57-8)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; nickel(II) bromide dimethoxyethane; N,N-dimethyl acetamide; [Ir(dF(H)ppy)₂(dtbbpy)](PF₆); at 55 ℃; for 48h; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1021/jacs.6b09533

upstream raw materials:

4-(4-(trifluoromethoxy)phenyl)piperidine

4-fluorobenzonitrile

4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester

4-Cyanochlorobenzene

Downstream raw materials:

7-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide

6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide

(4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methanamine