10-chloro-5-(cyclohexylimino)-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

Base Information

Chemical Name:10-chloro-5-(cyclohexylimino)-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one
CAS No.:1452386-68-3
Molecular Formula:C₂₈H₂₇ClN₄O
Molecular Weight:471.002
Hs Code.:

Synonyms:10-chloro-5-(cyclohexylimino)-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

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Chemical Property of 10-chloro-5-(cyclohexylimino)-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

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Technology Process of 10-chloro-5-(cyclohexylimino)-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

There total 3 articles about 10-chloro-5-(cyclohexylimino)-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 931-53-3
Cyclohexyl isocyanide

: 1452386-56-9
2-(2-bromophenyl)-6-chloro-1-methyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one

: 1452386-68-3
10-chloro-5-(cyclohexylimino)-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

Guidance literature:: With palladium diacetate; caesium carbonate; In toluene; at 110 ℃; for 24h; Sealed tube;
DOI:10.1055/s-0033-1338936

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1452386-68-3
10-chloro-5-(cyclohexylimino)-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / Reflux

1.2: 81 °C

2.1: palladium diacetate; caesium carbonate / toluene / 24 h / 110 °C / Sealed tube

With palladium diacetate; caesium carbonate; In toluene; acetonitrile;
DOI:10.1055/s-0033-1338936

Reference yield:

: 100-63-0
phenylhydrazine

: 1452386-68-3
10-chloro-5-(cyclohexylimino)-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / Reflux

1.2: 81 °C

2.1: palladium diacetate; caesium carbonate / toluene / 24 h / 110 °C / Sealed tube

With palladium diacetate; caesium carbonate; In toluene; acetonitrile;
DOI:10.1055/s-0033-1338936